DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wwox and spidey

DIOPT Version :9

Sequence 1:	NP_001285735.1	Gene:	Wwox / 34090	FlyBaseID:	FBgn0031972	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_572420.1	Gene:	spidey / 31703	FlyBaseID:	FBgn0029975	Length:	321	Species:	Drosophila melanogaster

Alignment Length:	221	Identity:	46/221 - (20%)
Similarity:	88/221 - (39%)	Gaps:	40/221 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 GRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAALDLSS 185
            |..|::||:..|||...|:.||..|.:::...|:........:.|..:...   ..|...:|.:.
  Fly    52 GEWAVVTGSTDGIGKAYAKELARRGLKLVLISRSLEKLNVVAKEIGDKYGV---EVRVIDVDFTG 113

  Fly   186 LRSVQRFVEEIKQSVSHIDYLILNAGV------FAL-------PYTRTVDGLETTFQVSHLSHFY 237
            ...:...:.| |.:..::..|:.|.|:      :.|       |:.|.:.. .....|:|::..:
  Fly   114 GDEIYDKIRE-KTTGLNVGVLVNNVGISYGHPEYFLDCYKADPPFLRNIVA-ANIHSVTHMTALF 176

  Fly   238 LTLQLETLFDYKTRIIVLSSESHRFANLPVENLAVHHLSPPPEKYWSMMAYNNAKLCNVLFAQEL 302
            |...:.   ..:..||.:||.:....|            |....|.|..|:.|.      |:.:|
  Fly   177 LPGMIS---QRRGVIINVSSTAGVIPN------------PLLSVYSSTKAFVNK------FSDDL 220

  Fly   303 AQRWKQRGISVFSLHPGNMVSSDLSR 328
            ...:|:.||.:.|:.|| .|::::|:
  Fly   221 QTEYKEHGILIQSVQPG-FVATNMSK 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_001285735.1	WW	13..43	CDD:197736
		WW	54..86	CDD:197736
		PRK06196	104..402	CDD:235736	46/221 (21%)
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	46/221 (21%)
spidey	NP_572420.1	PLN02780	8..321	CDD:166421	46/221 (21%)
spidey	NP_572420.1	17beta-HSD1_like_SDR_c	52..288	CDD:187614	46/221 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447529
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930