DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wwox and Rdh12

DIOPT Version :9

Sequence 1:	NP_001285735.1	Gene:	Wwox / 34090	FlyBaseID:	FBgn0031972	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001101507.1	Gene:	Rdh12 / 314264	RGDID:	1310462	Length:	316	Species:	Rattus norvegicus

Alignment Length:	303	Identity:	114/303 - (37%)
Similarity:	165/303 - (54%)	Gaps:	31/303 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 CSTALQVLHGKDLHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPA 171
            |:|.:|:      .|:..:|||||.|||.||||.||..|..:..|||:....|:|...|..:  .
  Rat    31 CTTKVQI------PGKVVVITGANTGIGKETARELARRGARVYIACRDVLKGESAASEIRAD--T 87

  Fly   172 ARSRCRFAALDLSSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHF 236
            ..|:.....||||..:|::.|.|........:..||.||||...||::||||.||.|.|:||.||
  Rat    88 KNSQVLVRKLDLSDTKSIRTFAEGFLAEEKKLHILINNAGVMMCPYSKTVDGFETHFGVNHLGHF 152

  Fly   237 YLT-LQLETLFD-YKTRIIVLSSESH-----RFANLPVENLAVHHLSPPPEKYWSMMAYNNAKLC 294
            .|| |.|..|.: ...|:|.|||.:|     ||.:|..:           ::|.|..||:::||.
  Rat   153 LLTYLLLGRLKESAPARVINLSSVAHLGGKIRFHDLQSK-----------KRYCSGFAYSHSKLA 206

  Fly   295 NVLFAQELAQRWKQRGISVFSLHPGNMVSSDLSRNYWFYRLLFAIVRPFTKSLQQAAATSIYCAT 359
            ||||.:|||:|.:..|::.:.:||| .|.|:::|:.:...||:.:..||.||..|.|.||::||.
  Rat   207 NVLFTRELAKRLQGTGVTAYVVHPG-CVLSEITRHSFLMCLLWRLFSPFFKSPWQGAQTSLHCAL 270

  Fly   360 ANELTGLSGLYFNNC--FFCEPSKLSKSAALQQQLWKLSENLI 400
            ...|..|||.||::|  .:..|...:|..|  ::||.:|..|:
  Rat   271 EEGLEPLSGKYFSDCKRTWVSPRARNKKTA--ERLWNVSCELL 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_001285735.1	WW	13..43	CDD:197736
		WW	54..86	CDD:197736
		PRK06196	104..402	CDD:235736	114/303 (38%)
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	111/289 (38%)
Rdh12	NP_001101507.1	NADB_Rossmann	39..307	CDD:419666	109/283 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810