DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wwox and Dhrs13

DIOPT Version :9

Sequence 1:	NP_001285735.1	Gene:	Wwox / 34090	FlyBaseID:	FBgn0031972	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	XP_038943561.1	Gene:	Dhrs13 / 303275	RGDID:	1305508	Length:	375	Species:	Rattus norvegicus

Alignment Length:	293	Identity:	108/293 - (36%)
Similarity:	151/293 - (51%)	Gaps:	28/293 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 LHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAALDL 183
            |.||||::||||.|||..||..||..|..::.|||:|...|||...:.||  :..:...|.||||
  Rat    34 LRGRTAVVTGANSGIGKMTALELARRGARVVLACRSRERGEAAAFDLRQE--SGNNEVIFMALDL 96

  Fly   184 SSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFYLT-LQLETLFD 247
            :||.|||.|......|...:|.||.|||:.:...||....|  ..:|:|:..|.|| |.|..|..
  Rat    97 ASLTSVQAFATAFLSSEPRLDILIHNAGISSCGRTRETFNL--LLRVNHVGPFLLTHLLLPRLRS 159

  Fly   248 -YKTRIIVLSSESHRFANLPVENLAVHHLSPPPEKYW--SMMAYNNAKLCNVLFAQELAQRWKQR 309
             ..:|::::||.:||...|....|..      |...|  .:.||.::||.|||||:|||.:.:..
  Rat   160 CAPSRVVIVSSAAHRRGRLDFTRLDC------PVVGWQQELRAYADSKLANVLFARELATQLEGT 218

  Fly   310 GISVFSLHPGNMVSSDLSRNYWFYRLLFAIVRPFTKSL--------QQAAATSIYCATANELTGL 366
            |::.::.||| .|:|:|     |.|.|...:||..:.|        |..|.|.:|||....:..|
  Rat   219 GVTCYAAHPG-PVNSEL-----FLRHLPGWLRPILRPLAWLVLRAPQGGAQTPLYCALQEGIEPL 277

  Fly   367 SGLYFNNCFFCEPSKLSKSAALQQQLWKLSENL 399
            ||.||.||...|.|..::......:|||:::.|
  Rat   278 SGRYFANCHVEEVSAAARDDQAAHRLWKVTKKL 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_001285735.1	WW	13..43	CDD:197736
		WW	54..86	CDD:197736
		PRK06196	104..402	CDD:235736	108/293 (37%)
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	107/291 (37%)
Dhrs13	XP_038943561.1	retinol-DH_like_SDR_c_like	36..304	CDD:212492	103/283 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810