DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wwox and SPAC19A8.06

DIOPT Version :9

Sequence 1:	NP_001285735.1	Gene:	Wwox / 34090	FlyBaseID:	FBgn0031972	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_593786.1	Gene:	SPAC19A8.06 / 2542391	PomBaseID:	SPAC19A8.06	Length:	397	Species:	Schizosaccharomyces pombe

Alignment Length:	319	Identity:	65/319 - (20%)
Similarity:	135/319 - (42%)	Gaps:	32/319 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 KDLHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAAL 181
            :.::|...::||.:.|||......||..|.:::...|.... :..::.|...|...:::..:..:
pombe    71 RKMNGMVVMVTGGSSGIGQVVVEKLASLGAQVVILLRTEPD-QFTVDYIMDLRKRTKNQLIYTEV 134

  Fly   182 -DLSSLRSVQRFVEEIKQ--SVSHIDYLILNAGVFALPY---TRTVDGLETTFQVSHLSHFYLTL 240
             ||||:.||::|..:...  .:..:|.::|.:||...|:   ..|.:|:|..:..:.|..:.|..
pombe   135 CDLSSMLSVRKFATKWIDCTPIRRLDMIVLCSGVLLPPFMDRQTTEEGVELQWATNFLGPYQLLR 199

  Fly   241 QLETLF-----DYKTRIIVLSSESHRFANLPVENLAVHHLSPPPEKYWSMMAYNNAKLCNVLFA- 299
            .|..:.     ..:.||:..:..|:...|:...:|.:.:...|.:..|.::  .||||..:.:.
pombe   200 ILRPVIYGQPGHREVRIVAATCSSYILGNIDFNDLDLSNHPYPRKSPWKVV--GNAKLALMTYLY 262

  Fly   300 --QELAQRWKQRGISVFSLH-----PGNMVSSDLSRNYWFYRL----LFAIVRPF----TKSLQQ 349
              |:.|:..::......:||     ||.:.:....|...|.::    |:.::.||    .|....
pombe   263 DFQKKAEAHERPDKMPCNLHTIMANPGVVRTPGFRRVVSFGKVWGLFLYLLLWPFWWLLLKGTIH 327

  Fly   350 AAATSIYCATANELTGLS-GLYFNNCFFCEPS-KLSKSAALQQQLWKLSENLIAELVEQ 406
            .|.:..:...:.|...:: .:..|.|...|.| |........::|.|.::..|.|:.:|
pombe   328 GAQSFFHAICSPEFASITQPVLVNECSIVEYSRKEITDPEFAEKLIKAADAQIDEVEKQ 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_001285735.1	WW	13..43	CDD:197736
		WW	54..86	CDD:197736
		PRK06196	104..402	CDD:235736	63/313 (20%)
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	63/309 (20%)
SPAC19A8.06	NP_593786.1	retinol-DH_like_SDR_c_like	75..372	CDD:212492	60/299 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24320
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000