DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wwox and Dhrsx

DIOPT Version :9

Sequence 1:	NP_001285735.1	Gene:	Wwox / 34090	FlyBaseID:	FBgn0031972	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001028498.2	Gene:	Dhrsx / 236082	MGIID:	2181510	Length:	335	Species:	Mus musculus

Alignment Length:	287	Identity:	91/287 - (31%)
Similarity:	130/287 - (45%)	Gaps:	27/287 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 GRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAALDLSS 185
            ||.|::|||..|||..|||.||..|..::.|..:....:..:..|..|  ....|..|..|||:|
Mouse    43 GRVAIVTGATAGIGRSTARQLARLGMCVVVAGNDEHCGQEVVSSIRAE--MGSDRAHFLPLDLAS 105

  Fly   186 LRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFYLTLQLETLFDYK- 249
            |.||:.|..:.:.....:..|:.||||...|...|.||.|....|:.|.||.|||.|.......
Mouse   106 LASVRGFARDFRALGLPLHLLVNNAGVMLEPRAETEDGFERHLGVNFLGHFLLTLLLLPALRASG 170

  Fly   250 -----TRIIVLSSESHRFANLPVENLAVHHLSPPPEKYWSMMAYNNAKLCNVLFAQELAQRWKQR 309
                 :|::.:.|.:|....:.:.:|...|...|      ..||..:||...|||.:|.:....|
Mouse   171 AEGRGSRVVTVGSATHYVGTVDMADLHGRHAYSP------YAAYAQSKLALALFALQLQRILDAR 229

  Fly   310 GISVFS--LHPGNMVSSDLSRNY-WFYRLLFAIVRPFT-----KSLQQAAATSIYCATANELTGL 366
            |..|.|  ..|| :|.::|.|:. |..|    .|:.|.     ||.::.|.|.:|.|.|.||.|:
Mouse   230 GDPVTSNMADPG-VVDTELYRHAGWVLR----TVKRFLGWLVFKSPEEGAWTLVYAAAAPELEGV 289

  Fly   367 SGLYFNNCFFCEPSKLSKSAALQQQLW 393
            .|.|..:....||...::...||::||
Mouse   290 GGRYLRDEAEAEPLGTARDQELQRRLW 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_001285735.1	WW	13..43	CDD:197736
		WW	54..86	CDD:197736
		PRK06196	104..402	CDD:235736	91/287 (32%)
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	91/287 (32%)
Dhrsx	NP_001028498.2	PRK06197	38..324	CDD:235737	91/287 (32%)
Dhrsx	NP_001028498.2	retinol-DH_like_SDR_c_like	43..316	CDD:212492	89/285 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910