Protein Alignment Wwox and DC2.5

DIOPT Version :10

• Sequence 1: NP_609171.1
• Gene: Wwox / 34090
• FlyBaseID: FBgn0031972
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: NP_503155.4
• Gene: DC2.5 / 183970
• WormBaseID: WBGene00017082
• Length: 337
• Species: Caenorhabditis elegans
• Alignment Length: 312
• Identity: 110/312 - (35%)
• Similarity: 169/312 - (54%)
• Gaps: 16/312 - (5%)

  Fly   102 QRFDSCSTALQVLHGKDLHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIA 166
            ::|.|.:.||:|:.|.||.|:|..|||...|:|.||||:....|..|:...||.:::|...:.:.
 Worm    26 RKFHSRTNALEVVRGIDLSGKTYAITGTTSGVGTETARAFILKGAHIVMINRNYAASETLKQSLL 90

  Fly   167 QERPAAR---SRCRFAALDLSSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTF 228
            .|.|.||   .:|     |||||.||::..||.......:..|||||||.......|.|..|..|
 Worm    91 CETPDARIDIVQC-----DLSSLASVKKTAEEYLTKKWPLHGLILNAGVLGRKEKTTADRFEAHF 150

  Fly   229 QVSHLSHFYLTLQLETLF--DYKTRIIVLSSESHRFANLPVENLAVHHLS---PPPEKYWSMMAY 288
            .::||:||.|..:|..:.  ...:||::|||...:|.::..::.....|.   |.....|....|
 Worm   151 GINHLAHFLLIKELLPVLRSSAPSRIVILSSTLSKFTSINPDSKIEEKLGTLCPKNATEWYYRLY 215

  Fly   289 NNAKLCNVLFAQELAQRWKQRGISVFSLHPGNMVSSDLSRNYWFYRLLFAIVRPFTKSLQQAAAT 353
            ..:|:||:|.|.:|.:...:.||||:|:|||:.|.::|.|:..|:.:...:..||||:..|.|||
 Worm   216 AKSKMCNMLIAFKLHRDEFENGISVYSVHPGSAVRTNLHRDVPFWSIFNFLSIPFTKNASQGAAT 280

  Fly   354 SIYCATANELTGLSGLYFNNCFFCE---PSKLSKSAALQQQLWKLSENLIAE 402
            |:|||...|:..|||.|:.:|:..|   ..|:::...||:.||:.||.|:.:
 Worm   281 SLYCAVHPEVQELSGRYWESCWDDELNLDEKVARDEELQEALWEYSEELVGK 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_609171.1	WW	13..43	CDD:197736
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	102/291 (35%)
DC2.5	NP_503155.4	retinol-DH_like_SDR_c_like	45..323	CDD:212492	97/282 (34%)