DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wwox and Rdh11

DIOPT Version :9

Sequence 1:	NP_001285735.1	Gene:	Wwox / 34090	FlyBaseID:	FBgn0031972	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_067532.2	Gene:	Rdh11 / 17252	MGIID:	102581	Length:	316	Species:	Mus musculus

Alignment Length:	312	Identity:	112/312 - (35%)
Similarity:	170/312 - (54%)	Gaps:	31/312 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 QVRQRFDS--CSTALQVLHGKDLHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAA 161
            ::|:...|  |::.:|      |.|:.|::||||.|||.|||:.||..|..:..|||:....|.|
Mouse    20 KIRKMLSSGVCTSNVQ------LPGKVAIVTGANTGIGKETAKDLAQRGARVYLACRDVDKGELA 78

  Fly   162 IERIAQERPAARSRCRFAALDLSSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLET 226
            ...|  :.....|:.....|||:..:|::.|.::......|:..||.||||...||::|.||.|.
Mouse    79 AREI--QAVTGNSQVFVRKLDLADTKSIRAFAKDFLAEEKHLHLLINNAGVMMCPYSKTADGFEM 141

  Fly   227 TFQVSHLSHFYLT-LQLETLFD-YKTRIIVLSSESHRFANLPVENLAVHHLSPPPEKYWSM-MAY 288
            ...|:||.||.|| |.||.|.: ..:||:.|||..|....:...||       ..||::|. :||
Mouse   142 HIGVNHLGHFLLTHLLLEKLKESAPSRIVNLSSLGHHLGRIHFHNL-------QGEKFYSAGLAY 199

  Fly   289 NNAKLCNVLFAQELAQRWKQRGISVFSLHPGNMVSSDLSRNY-----WFYRLLFAIVRPFTKSLQ 348
            .::||.|:||.:|||:|.|..|::.:|:|||. |.|:|:| |     |.::|.|.    |.|:.|
Mouse   200 CHSKLANILFTKELAKRLKGSGVTTYSVHPGT-VHSELTR-YSSIMRWLWQLFFV----FIKTPQ 258

  Fly   349 QAAATSIYCATANELTGLSGLYFNNCFFCEPSKLSKSAALQQQLWKLSENLI 400
            :.|.||:|||....|..|||.:|::|.....|...::..:.::||.:|.:|:
Mouse   259 EGAQTSLYCALTEGLESLSGSHFSDCQLAWVSYQGRNEIIARRLWDVSCDLL 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_001285735.1	WW	13..43	CDD:197736
		WW	54..86	CDD:197736
		PRK06196	104..402	CDD:235736	111/307 (36%)
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	107/288 (37%)
Rdh11	NP_067532.2	PRK06197	38..311	CDD:235737	107/288 (37%)
Rdh11	NP_067532.2	NADB_Rossmann	38..306	CDD:304358	105/282 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.710