DRSC/TRiP Functional Genomics Resources

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Protein Alignment Wwox and RDH12

DIOPT Version :9

Sequence 1:NP_001285735.1 Gene:Wwox / 34090 FlyBaseID:FBgn0031972 Length:409 Species:Drosophila melanogaster
Sequence 2:NP_689656.2 Gene:RDH12 / 145226 HGNCID:19977 Length:316 Species:Homo sapiens


Alignment Length:297 Identity:110/297 - (37%)
Similarity:161/297 - (54%) Gaps:19/297 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly   107 CSTALQVLHGKDLHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPA 171
            |.|.:|      |.|:..:|||||.|||.||||.||..|..:..|||:....|:|...|..:  .
Human    31 CRTNVQ------LPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVD--T 87

  Fly   172 ARSRCRFAALDLSSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHF 236
            ..|:.....||||..:|::.|.|........:..||.||||...||::|.||.||...|:||.||
Human    88 KNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHF 152

  Fly   237 YLT-LQLETL-FDYKTRIIVLSSESHRFANLPVENLAVHHLSPPPEKYWSM-MAYNNAKLCNVLF 298
            .|| |.||.| .....|::.:||.:|....:|..:|       ..||.:|. .||.::||.||||
Human   153 LLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDL-------QSEKRYSRGFAYCHSKLANVLF 210

  Fly   299 AQELAQRWKQRGISVFSLHPGNMVSSDLSRNYWFYRLLFAIVRPFTKSLQQAAATSIYCATANEL 363
            .:|||:|.:..|::.:::||| :|.|:|.|:.....||:.:..||.|:.::.|.||::||.|..|
Human   211 TRELAKRLQGTGVTTYAVHPG-VVRSELVRHSSLLCLLWRLFSPFVKTAREGAQTSLHCALAEGL 274

  Fly   364 TGLSGLYFNNCFFCEPSKLSKSAALQQQLWKLSENLI 400
            ..|||.||::|.....|..:::....::||.:|..|:
Human   275 EPLSGKYFSDCKRTWVSPRARNNKTAERLWNVSCELL 311

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WwoxNP_001285735.1 WW 13..43 CDD:197736
WW 54..86 CDD:197736
PRK06196 104..402 CDD:235736 110/297 (37%)
human_WWOX_like_SDR_c-like 121..402 CDD:187669 106/283 (37%)
RDH12NP_689656.2 retinol-DH_like_SDR_c 39..307 CDD:212495 104/277 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1208
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000061
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100091
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X72
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.710

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