DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wwox and Rdh13

DIOPT Version :9

Sequence 1:	NP_001285735.1	Gene:	Wwox / 34090	FlyBaseID:	FBgn0031972	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_780581.1	Gene:	Rdh13 / 108841	MGIID:	1918732	Length:	334	Species:	Mus musculus

Alignment Length:	288	Identity:	104/288 - (36%)
Similarity:	155/288 - (53%)	Gaps:	16/288 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 GRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAALDLSS 185
            |:|.::||||.|||.:||..||..|..:|.|||:....|.|.:.|..|  ....|.|...|||:|
Mouse    38 GKTVIVTGANTGIGKQTALELAKRGGNVILACRDMEKCEVAAKDIRGE--TLNPRVRAERLDLAS 100

  Fly   186 LRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFYLT-LQLETL-FDY 248
            |:|::.|..::.:....:|.|:.||.|...|:..|.||.|..|.|::|.||.|| |.|:.| ...
Mouse   101 LKSIREFARKVIKEEERVDILVNNAAVMRCPHWTTEDGFEMQFGVNYLGHFLLTNLLLDKLKASA 165

  Fly   249 KTRIIVLSSESHRFANLPVENLAVHHLSPPPEKYWSMMAYNNAKLCNVLFAQELAQRWKQRGISV 313
            .:|||.|||.:|...::..|:     |:...:||.:..||..:||..|||.:||:.|.:..|::|
Mouse   166 PSRIINLSSLAHVAGHIDFED-----LNWQMKKYDTKAAYCQSKLAVVLFTKELSHRLQGSGVTV 225

  Fly   314 FSLHPGNMVSSDLSRNYWFYRLLFA--IVRPF----TKSLQQAAATSIYCATANELTGLSGLYFN 372
            .:|||| :..::|.|:...:...|:  ::.||    .||.|.||..|.|.|.|.||..:||.||:
Mouse   226 NALHPG-VARTELGRHTGMHNSAFSGFMLGPFFWLLFKSPQLAAQPSTYLAVAEELENVSGKYFD 289

  Fly   373 NCFFCEPSKLSKSAALQQQLWKLSENLI 400
            ......||..::...:.::||..|..|:
Mouse   290 GLREKAPSPEAEDEEVARRLWTESARLV 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_001285735.1	WW	13..43	CDD:197736
		WW	54..86	CDD:197736
		PRK06196	104..402	CDD:235736	104/288 (36%)
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	104/288 (36%)
Rdh13	NP_780581.1	NADB_Rossmann	38..313	CDD:419666	102/282 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.710