DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wwox and si:dkey-73n8.3

DIOPT Version :9

Sequence 1:	NP_001285735.1	Gene:	Wwox / 34090	FlyBaseID:	FBgn0031972	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001186991.1	Gene:	si:dkey-73n8.3 / 100150965	ZFINID:	ZDB-GENE-141219-27	Length:	296	Species:	Danio rerio

Alignment Length:	288	Identity:	103/288 - (35%)
Similarity:	160/288 - (55%)	Gaps:	20/288 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 LHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAALDL 183
            |.|:||::||||.|||.|||:.||:.|..:|.|||:...||.|...|:::...|....|  .|||
Zfish    18 LDGKTAIVTGANTGIGKETAKDLANRGARVILACRDLVKAEQAASDISRDVENANVVVR--KLDL 80

  Fly   184 SSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFYLTLQLETLFDY 248
            :..:|:..|.|.|..:...:..||.||||...||:.||||.||.|.|:||.||:||..|..|..:
Zfish    81 ADTKSICEFAELIYNTEKSLHLLINNAGVAICPYSTTVDGFETQFGVNHLGHFFLTFLLIDLLKH 145

  Fly   249 K--TRIIVLSSESHRFANLPVENLAVHHLSPPPEKYWSMMAYNNAKLCNVLFAQELAQRWKQRGI 311
            .  :|:|.:||..|....:..|:|      ...:.|..:.||..:||.|:||.:|||.|.::.|:
Zfish   146 SAPSRVINVSSLVHPMGKIHFEDL------NSEKNYHPVKAYVQSKLANILFTRELASRVEELGV 204

  Fly   312 SVFSLHPGNMVSSDLSRNYW----FYRLLFAIVRPFTKSLQQAAATSIYCATANELTGLSGLYFN 372
            .|:::.|| :|::|::|:..    |:...|..:   .|:..:.|.|::|||...:|.  :|.|::
Zfish   205 RVYAVDPG-LVNTDITRHLMKPVQFFVKTFGFM---IKTPAEGAYTTLYCALTPDLP--TGSYYS 263

  Fly   373 NCFFCEPSKLSKSAALQQQLWKLSENLI 400
            ||.....|:.:|......:||.:|.:|:
Zfish   264 NCAVASCSRAAKDDNSASKLWAVSCHLL 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_001285735.1	WW	13..43	CDD:197736
		WW	54..86	CDD:197736
		PRK06196	104..402	CDD:235736	103/288 (36%)
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	102/286 (36%)
si:dkey-73n8.3	NP_001186991.1	PRK06197	19..295	CDD:235737	102/287 (36%)
si:dkey-73n8.3	NP_001186991.1	NADB_Rossmann	20..287	CDD:304358	100/280 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910