Protein Alignment Wwox and si:dkey-94e7.2

DIOPT Version :10

• Sequence 1: NP_609171.1
• Gene: Wwox / 34090
• FlyBaseID: FBgn0031972
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: XP_017212892.1
• Gene: si:dkey-94e7.2 / 100141353
• ZFINID: ZDB-GENE-070912-611
• Length: 302
• Species: Danio rerio
• Alignment Length: 291
• Identity: 110/291 - (37%)
• Similarity: 163/291 - (56%)
• Gaps: 18/291 - (6%)

  Fly   119 LHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAALDL 183
            |..:|.:|||||.|||.||.:.||..|..||.|||:...||.|...|.:|  :.........|||
Zfish    22 LDDKTIIITGANTGIGKETTKDLAKRGPRIIMACRDVEKAERAQREIMEE--SGNQNIVIRKLDL 84

  Fly   184 SSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFYLTLQLETLF-- 246
            |..||::.|.|.|......:..||.||||...||::|.||.|..|.|:||.||.||..|..|.
Zfish    85 SDTRSIREFAEVINSEERSLHLLINNAGVMMCPYSKTADGFEMQFGVNHLGHFLLTFLLIDLLKR 149

  Fly   247 DYKTRIIVLSSESHRFANLPVENLAVHHLSPPPEKYWSMMAYNNAKLCNVLFAQELAQRWKQRGI 311
            ...:|||.|||.:|.:..:.::::      .....|.|..||..:||.|:||.:.||::.|..|:
Zfish   150 SAPSRIINLSSMAHSWGTITLDDI------NSERNYHSRRAYGQSKLANILFTRSLAKKLKDTGV 208

  Fly   312 SVFSLHPGNMVSSDLSRNYWF-YRLLFAIVRPFTKSLQQAAATSIYCATANELTGLSGLYFNNCF 375
            :.:::||| :|.::|.|:... ..:::.:||||||:..|.|.|:||||...||...||.|:::
Zfish   209 TSYAVHPG-IVRTELKRHMNLGLLIMWKVVRPFTKTPVQGAQTTIYCAVQPELDAESGGYYSD-- 270

  Fly   376 FCEPSKLSKSA---ALQQQLWKLSENLIAEL 403
             |.||:.:::|   .:.::||:||.|::..|
Zfish   271 -CRPSRCTRAARDDEMAEKLWELSCNMLGIL 300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_609171.1	WW	13..43	CDD:197736
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	108/286 (38%)
si:dkey-94e7.2	XP_017212892.1	Rossmann-fold NAD(P)(+)-binding proteins	25..293	CDD:473865	105/279 (38%)