Protein Alignment CG7227 and SCARB2

DIOPT Version :9

• Sequence 1: NP_001245934.1
• Gene: CG7227 / 34088
• FlyBaseID: FBgn0031970
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: NP_005497.1
• Gene: SCARB2 / 950
• HGNCID: 1665
• Length: 478
• Species: Homo sapiens
• Alignment Length: 466
• Identity: 129/466 - (27%)
• Similarity: 221/466 - (47%)
• Gaps: 35/466 - (7%)

  Fly    10 TSVLGLLLASFSLFSVLYMEQIERWMLEWFMVLRPGTMISSLWQSPAMDINVDLYIFNWTNSEKF 74
            |..|.||:.|.:|......::.....:|..:|||.||.....|:.|.:.:....|.||.||.|:.
Human    11 TLSLLLLVTSVTLLVARVFQKAVDQSIEKKIVLRNGTEAFDSWEKPPLPVYTQFYFFNVTNPEEI 75

  Fly    75 SDPTVKPRFEELGPYRFTERMQKVNVEWHDENSTVSYRRRSRFDFDPKLSVGRP-TDPIVAPNLL 138
            ..... ||.||:|||.:.|...|.|:::.|..:|:|......:.|:...|||.| .|.|...|:.
Human    76 LRGET-PRVEEVGPYTYRELRNKANIQFGDNGTTISAVSNKAYVFERDQSVGDPKIDLIRTLNIP 139

  Fly   139 IVGLYQKMVMWSPM--LRSLMLLALNIYGKEQAMIRPASDWMFDGFDTPMIKMSKMVPPSLVPEM 201
            ::    .::.||.:  ||.::...|..| :::..:....|.:..|:...::.:..:..|.:.|
Human   140 VL----TVIEWSQVHFLREIIEAMLKAY-QQKLFVTHTVDELLWGYKDEILSLIHVFRPDISP-- 197

  Fly   202 KFPYEKIGYAYPRNGSMEIYGHHNVYTGRDEFQKLGQIARWRYNNVTE----ASPRCK-LKGSAG 261
                 ..|..|.:||:.:  |.:...||.|.:....:|..|  |..|.    .:.:|. :.|:.|
Human   198 -----YFGLFYEKNGTND--GDYVFLTGEDSYLNFTKIVEW--NGKTSLDWWITDKCNMINGTDG 253

  Fly   262 E-FHPIPLVKGRPISYFLPDLCRELQVDYSGTTIFEGIDAFVYRGSARNMANGTDNPDNSCYCQD 325
            : |||: :.|...:..|..|.||.:.:.:|.....:|:.||.|:..|..:||.:||. ..|..:.
Human   254 DSFHPL-ITKDEVLYVFPSDFCRSVYITFSDYESVQGLPAFRYKVPAEILANTSDNA-GFCIPEG 316

  Fly   326 NCQEVRSGLLNISSCWYGTPVFASYPHFFKADPYYGEQVEGMKPDKDRHEMVIMLEPKTGMVLEI 390
            ||  :.||:||:|.|..|.|:..|:|||::||..:...:|||.|:::.||..:.:.|.||::|:.
Human   317 NC--LGSGVLNVSICKNGAPIIMSFPHFYQADERFVSAIEGMHPNQEDHETFVDINPLTGIILKA 379

  Fly   391 KARIMANLLVEPKTHLIYRTARRTF-FPLIWADYNVRITDDLLVYVKLM----PILEFVGKICGI 450
            ..|...|:.|:.....:.....||. ||:::.:.:|.|..:....:|.|    .|:..:..|...
Human   380 AKRFQINIYVKKLDDFVETGDIRTMVFPVMYLNESVHIDKETASRLKSMINTTLIITNIPYIIMA 444

  Fly   451 LGVVLGLLMVF 461
            |||..||:..:
Human   445 LGVFFGLVFTW 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7227	NP_001245934.1	CD36	13..463	CDD:279474	128/463 (28%)
SCARB2	NP_005497.1	CD36	28..455	CDD:307331	123/447 (28%)
		Important for interaction with GBA	155..191		4/36 (11%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45589
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11923
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.930