DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7227 and CD36

DIOPT Version :9

Sequence 1:	NP_001245934.1	Gene:	CG7227 / 34088	FlyBaseID:	FBgn0031970	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_000063.2	Gene:	CD36 / 948	HGNCID:	1663	Length:	472	Species:	Homo sapiens

Alignment Length:	469	Identity:	122/469 - (26%)
Similarity:	218/469 - (46%)	Gaps:	52/469 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SVLGLLLASFS-----LFSVLYMEQIERWMLEWFMVLRPGTMISSLWQSPAMDINVDLYIFNWTN 70
            :|:|.:||.|.     :..:|..:.|::.     :||..||:....|.....::....:||:..|
Human    13 AVIGAVLAVFGGILMPVGDLLIQKTIKKQ-----VVLEEGTIAFKNWVKTGTEVYRQFWIFDVQN 72

  Fly    71 SEKFSDPTVKPRFEELGPYRFTER-MQKVNVEWHDENSTVSYRRRSRFDFDPKLSVGRPTDPIVA 134
            .::....:...:.::.|||.:..| :.|.||....|::|||:.:.:...|:|.||||...|....
Human    73 PQEVMMNSSNIQVKQRGPYTYRVRFLAKENVTQDAEDNTVSFLQPNGAIFEPSLSVGTEADNFTV 137

  Fly   135 PNLLIVG---LYQKMVMWSPMLRSLMLLALNIYGKEQAMIRPASDWMFDGFDTPMIKMSKMVPPS 196
            .||.:..   :||...: ..:|.||    :|........:|...:.:: |:..|.:        |
Human   138 LNLAVAAASHIYQNQFV-QMILNSL----INKSKSSMFQVRTLRELLW-GYRDPFL--------S 188

  Fly   197 LVPEMKFPY-EKIGYAYPRNGSMEIYGHHNVYTGRDEFQKLGQIARWR-YNNVTEASPRC-KLKG 258
            |||   :|. ..:|..||.|.:.:  |.:.|:.|:|...|:..|..:: ..|::.....| .:.|
Human   189 LVP---YPVTTTVGLFYPYNNTAD--GVYKVFNGKDNISKVAIIDTYKGKRNLSYWESHCDMING 248

  Fly   259 S-AGEFHPIPLVKGRPISYFLPDLCRELQVDYSGTTIFEGIDAFVYRGSARNMANGTDNPDNSCY 322
            : |..|.|. :.|.:.:.:|..|:||.:...:......:||..:.:...::..|:..:||||.|:
Human   249 TDAASFPPF-VEKSQVLQFFSSDICRSIYAVFESDVNLKGIPVYRFVLPSKAFASPVENPDNYCF 312

  Fly   323 CQD-----NCQEVRSGLLNISSCWYGTPVFASYPHFFKADPYYGEQVEGMKPDKDRHEMVIMLEP 382
            |.:     ||...  |:|:||.|..|.||:.|.|||..|.|...|.::|:.|:::.|...:.:||
Human   313 CTEKIISKNCTSY--GVLDISKCKEGRPVYISLPHFLYASPDVSEPIDGLNPNEEEHRTYLDIEP 375

  Fly   383 KTGMVLEIKARIMANLLVEP--KTHLIYRTARRTFFPLIWADYNVRITDDLLVYVKLMPILEFVG 445
            .||..|:...|:..||||:|  |..::....|....|::|.:....|.|:.....:    .:..|
Human   376 ITGFTLQFAKRLQVNLLVKPSEKIQVLKNLKRNYIVPILWLNETGTIGDEKANMFR----SQVTG 436

  Fly   446 KICGILGVVLGLLM 459
            || .:||::..:|:
Human   437 KI-NLLGLIEMILL 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7227	NP_001245934.1	CD36	13..463	CDD:279474	121/467 (26%)
CD36	NP_000063.2	CD36	14..463	CDD:395898	122/468 (26%)
		Required for interaction with thrombospondins, THBS1 and THBS2. /evidence=ECO:0000269\|PubMed:1371676	93..120		8/26 (31%)
		Interaction with PTK2, PXN and LYN. /evidence=ECO:0000269\|PubMed:20037584	460..472
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	1.030639	Normalized mean entropy	S6187
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.770