DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7227 and Cd36

DIOPT Version :9

Sequence 1:	NP_001245934.1	Gene:	CG7227 / 34088	FlyBaseID:	FBgn0031970	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001153027.1	Gene:	Cd36 / 12491	MGIID:	107899	Length:	472	Species:	Mus musculus

Alignment Length:	484	Identity:	129/484 - (26%)
Similarity:	215/484 - (44%)	Gaps:	76/484 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SVLGLLLASFS-----LFSVLYMEQIERWMLEWFMVLRPGTMISSLWQSPAMDINVDLYIFNWTN 70
            :|:|.:||.|.     :..:|..:.|:|     .:||..||.....|......:....:||:..|
Mouse    13 AVIGAVLAVFGGILMPVGDMLIEKTIKR-----EVVLEEGTTAFKNWVKTGTTVYRQFWIFDVQN 72

  Fly    71 SEKFSDPTVKPRFEELGPYRFTER-MQKVNVEWHDENSTVSYRRRSRFDFDPKLSVGRPTDPIVA 134
            .:..:..:.|.:.::.|||.:..| :.|.|:....|:.|||:.:.:...|:|.||||...|....
Mouse    73 PDDVAKNSSKIKVKQRGPYTYRVRYLAKENITQDPEDHTVSFVQPNGAIFEPSLSVGTEDDNFTV 137

  Fly   135 PNLLIVG---LYQKMVMWSPMLRSLMLLALNIYGKEQAMIRPASDWMFD---------GFDTPMI 187
            .||.:..   :||         .|.:.:.||      ::|:.:...||.         |:..|.:
Mouse   138 LNLAVAAAPHIYQ---------NSFVQVVLN------SLIKKSKSSMFQTRSLKELLWGYKDPFL 187

  Fly   188 KMSKMVPPSLVPEMKFPYE-KIGYAYPRNGSMEIYGHHNVYTGRDEFQKLGQIARWR-YNNVTEA 250
                    ||||   :|.. .:|..||.|.:::  |.:.|:.|:|...|:..|..:: ..|::..
Mouse   188 --------SLVP---YPISTTVGVFYPYNDTVD--GVYKVFNGKDNISKVAIIESYKGKRNLSYW 239

  Fly   251 SPRC-KLKGS-AGEFHPIPLVKGRPISYFLPDLCRELQVDYSGTTIFEGIDAFVYRGSARNMANG 313
            ...| .:.|: |..|.|. :.|.|.:.:|..|:||.:...:......:||..:.:...|...|:.
Mouse   240 PSYCDMINGTDAASFPPF-VEKSRTLRFFSSDICRSIYAVFGSEIDLKGIPVYRFVLPANAFASP 303

  Fly   314 TDNPDNSCYC-----QDNCQEVRSGLLNISSCWYGTPVFASYPHFFKADPYYGEQVEGMKPDKDR 373
            ..||||.|:|     .:||...  |:|:|..|..|.||:.|.|||..|.|...|.:||:.|::|.
Mouse   304 LQNPDNHCFCTEKVISNNCTSY--GVLDIGKCKEGKPVYISLPHFLHASPDVSEPIEGLHPNEDE 366

  Fly   374 HEMVIMLEPKTGMVLEIKARIMANLLVEP--KTHLIYRTARRTFFPLIWADYNVRITDDLLVYVK 436
            |...:.:||.||..|:...|:..|:||:|  |...:....|....|::|.:....|.|:.....|
Mouse   367 HRTYLDVEPITGFTLQFAKRLQVNILVKPARKIEALKNLKRPYIVPILWLNETGTIGDEKAEMFK 431

  Fly   437 LMPILEFVGKICGILGVV------LGLLM 459
                .:..||| .:||:|      :|::|
Mouse   432 ----TQVTGKI-KLLGMVEMALLGIGVVM 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7227	NP_001245934.1	CD36	13..463	CDD:279474	128/482 (27%)
Cd36	NP_001153027.1	CD36	16..463	CDD:366481	128/481 (27%)
		Required for interaction with thrombospondins, THBS1 and THBS2. /evidence=ECO:0000269\|PubMed:15748999	93..120		7/26 (27%)
		Interaction with PTK2, PXN and LYN. /evidence=ECO:0000250\|UniProtKB:P16671	460..472
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	1.030639	Normalized mean entropy	S6187
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.760