DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7227 and Scarb2

DIOPT Version :9

Sequence 1:	NP_001245934.1	Gene:	CG7227 / 34088	FlyBaseID:	FBgn0031970	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_446453.1	Gene:	Scarb2 / 117106	RGDID:	621882	Length:	478	Species:	Rattus norvegicus

Alignment Length:	467	Identity:	127/467 - (27%)
Similarity:	218/467 - (46%)	Gaps:	37/467 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TSVLGLLLASFSLFSVLYMEQIERWMLEWFMVLRPGTMISSLWQSPAMDINVDLYIFNWTNSEKF 74
            |..|.||:.|.:|......::.....:|..|||:.||.:...|:.|.:.:.:..|.||.||.|:.
  Rat    11 TLSLLLLVTSVTLLVARVFQKAVDQTIEKNMVLQNGTKVFDSWEKPPLPVYIQFYFFNVTNPEEI 75

  Fly    75 SDPTVKPRFEELGPYRFTERMQKVNVEWHDENSTVSYRRRSRFDFDPKLSVGRPTDPIV----AP 135
            ....: |..||:|||.:.|...|.||::.:..:|:|......:.|:...|||.||..::    .|
  Rat    76 LQGEI-PLLEEVGPYTYRELRNKANVQFGENGTTISAVTNKAYIFERNQSVGDPTVDLIRTINIP 139

  Fly   136 NLLIVGLYQKMVMWSPMLRSLMLLALNIYGKEQAMIRPASDWMFDGFDTPMIKMSKMVPPSLVPE 200
            .|.:|.:.|:     |.||.::...|..|.:...:.....:.:: |:...::.:..:..|.:.|
  Rat   140 LLTVVEMAQQ-----PFLREIIEAMLKAYQQTLFVTHTVHELLW-GYKDEVLSLVHIFRPDVSP- 197

  Fly   201 MKFPYEKIGYAYPRNGSMEIYGHHNVYTGRDEFQKLGQIARWRYNNVTE----ASPRCK-LKGSA 260
                  ..|..|.|||:.:  |.:...||.|.:....:|..|  |..|.    .:..|. :.|:.
  Rat   198 ------NFGLFYERNGTND--GEYVFLTGEDNYLNFTKIVEW--NGKTSLDWWTTDTCNMINGTD 252

  Fly   261 GE-FHPIPLVKGRPISYFLPDLCRELQVDYSGTTIFEGIDAFVYRGSARNMANGTDNPDNSCYCQ 324
            |: |||: :.|...:..|..|.||.:.:.:|.....||:.||.|:..|..:||.::|. ..|..:
  Rat   253 GDSFHPL-ISKDETLYIFPSDFCRSVYITFSSFENVEGLPAFRYKVPAEILANSSENA-GFCIPE 315

  Fly   325 DNCQEVRSGLLNISSCWYGTPVFASYPHFFKADPYYGEQVEGMKPDKDRHEMVIMLEPKTGMVLE 389
            .||.:  :|:||:|.|..|.|:..|:|||::||..:...::||:|:|:.||..:.:.|.||::|.
  Rat   316 GNCMD--AGVLNVSICKNGAPIIMSFPHFYQADEKFVSAIKGMRPNKEEHESFVDINPLTGIILR 378

  Fly   390 IKARIMANLLVEPKTHLIYRTARRTF-FPLIWADYNVRI----TDDLLVYVKLMPILEFVGKICG 449
            ...|...|..|:.....:.....||. ||:::.:.:|.|    ...|...:....|:..:..|..
  Rat   379 GAKRFQINTYVKKLDDFVETGNIRTMVFPVMYLNESVLIDKETASQLKSVINTTLIVTNIPYIIM 443

  Fly   450 ILGVVLGLLMVF 461
            .|||..||:..:
  Rat   444 ALGVFFGLIFTW 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7227	NP_001245934.1	CD36	13..463	CDD:279474	126/464 (27%)
Scarb2	NP_446453.1	CD36	34..457	CDD:395898	121/444 (27%)
Scarb2	NP_446453.1	Important for interaction with GBA. /evidence=ECO:0000250	155..191		3/36 (8%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45589
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11923
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.930