DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pes and Cd36

DIOPT Version :9

Sequence 1:	NP_001137808.1	Gene:	pes / 34087	FlyBaseID:	FBgn0031969	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_113749.2	Gene:	Cd36 / 29184	RGDID:	2301	Length:	472	Species:	Rattus norvegicus

Alignment Length:	478	Identity:	124/478 - (25%)
Similarity:	224/478 - (46%)	Gaps:	38/478 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RHCARL-GIVLLGICCIASGIYLFRNWIDMFTRMRGQEMALSPNSRSFEGWKVSPLPLDFDIYLF 69
            |:|..: |.|:..:..:..||.:....: :..:...:|:.|...:.:|:.|..:...:....::|
  Rat     5 RNCGLITGAVIGAVLAVFGGILMPVGDL-LIEKTIKREVVLEEGTIAFKNWVKTGTTVYRQFWIF 68

  Fly    70 NWTNPDDFYVGSNKKPHFEQLGPYRFREK-PDKVDIEWHNHNASVSFHKKSWFYFDAAGSNGSLW 133
            :..||::....|: |...:|.|||.:|.: ..|.:|.....:::|||.:.:...|:.:.|.|:..
  Rat    69 DVQNPEEVAKNSS-KIKVKQRGPYTYRVRYLAKENITQDPKDSTVSFVQPNGAIFEPSLSVGTEN 132

  Fly   134 DKVTTVNSVAHSAARRAAVDWFARTGVNIANKLYRQGVTITKTVDEMLFKGYEHPFISVGKLLRP 198
            |..|.:| :|.:||.....:.|.:..:|...|..:..:..|:::.|:|: ||:.||:|:
  Rat   133 DNFTVLN-LAVAAAPHIYTNSFVQGVLNSLIKKSKSSMFQTRSLKELLW-GYKDPFLSL------ 189

  Fly   199 QDVPY---KRIGYHYPRNGSSEFDGDINMFTGADDIAKMGQIHTWNNLTHTGAFEGTCGQVHGSM 260
              |||   ..:|..||.|.:  .||...:|.|.|:|:|:..|.|:....:...:|..|..::|:.
  Rat   190 --VPYPISTTVGVFYPYNNT--VDGVYKVFNGKDNISKVAIIDTYKGKRNLSYWESYCDMINGTD 250

  Fly   261 GEFFPPNLGTKDTVYMYMPKMCRAIPLDYVETVTVHGVTAYKFSGTRHAVDNGTLYPDTRCYC-- 323
            ...|||.:....|:..:...:||:|...:...|.:.|:..|:|....:|..:....||..|:|
  Rat   251 AASFPPFVEKSRTLRFFSSDICRSIYAVFGSEVNLKGIPVYRFVLPANAFASPLQNPDNHCFCTE 315

  Fly   324 --VGGKCMPSGVINIGPCSFNASVYMSFPHFYMADPSYLEAIEGLRPEREKHEFFMALEPNAGVP 386
              :...|...||::||.|.....||:|.|||..|.|...|.||||.|..::|..::.:||..|..
  Rat   316 KVISNNCTSYGVLDIGKCKEGKPVYISLPHFLHASPDVSEPIEGLNPNEDEHRTYLDVEPITGFT 380

  Fly   387 MDVGGGFQANYYMEPIPGITLYENVP-TVMIPMMWCEERVRVSEE--------IAADIALVPLI- 441
            :......|.|..::|...|...:|:. ..::|::|..|...:.:|        :...|.|:.|:
  Rat   381 LQFAKRLQVNILVKPARKIEALKNLKRPYIVPILWLNETGTIGDEKAEMFRNQVTGKIKLLGLVE 445

  Fly   442 -VLLGQIVTGILLAGGLI--CTC 461
             ||||  |..::....:|  |.|
  Rat   446 MVLLG--VGVVMFVAFMISYCAC 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pes	NP_001137808.1	CD36	14..463	CDD:279474	121/469 (26%)
Cd36	NP_113749.2	CD36	14..463	CDD:395898	119/464 (26%)
		Required for interaction with thrombospondins, THBS1 and THBS2. /evidence=ECO:0000250	93..120		6/26 (23%)
		Interaction with PTK2, PXN and LYN. /evidence=ECO:0000250\|UniProtKB:P16671	460..472		3/7 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920