DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn28Da and SERPINB12

DIOPT Version :9

Sequence 1:	NP_001036345.1	Gene:	Spn28Da / 34082	FlyBaseID:	FBgn0051902	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	XP_005266835.2	Gene:	SERPINB12 / 89777	HGNCID:	14220	Length:	437	Species:	Homo sapiens

Alignment Length:	431	Identity:	113/431 - (26%)
Similarity:	201/431 - (46%)	Gaps:	75/431 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LVTTSVLGQFTKQLYRSFLQDNKQYNIIASPLCVEIGMSMILMGADGNTANELRTALNLPEDKKN 72
            |||.:.  :|...|::...:|::..||..|||.:...:.|:.:||..::|:::...|:..|..:|
Human    16 LVTANT--KFCFDLFQEIGKDDRHKNIFFSPLSLSAALGMVRLGARSDSAHQIDEVLHFNEFSQN 78

  Fly    73 ---------------------------------------------VATIYDKLLTKLERGKKVAI 92
                                                         |:..:.:||:||:|.|....
Human    79 ESKEPDPCLKSNKQKVLADSSLEGQKKTTEPLDQQAGSLNNESGLVSCYFGQLLSKLDRIKTDYT 143

  Fly    93 LHLANRLFVNETIGVNKRYNKLVNKHFRAEAEAIKL-ADRLKAAWAINDWVLDQTLDNVKDIIIP 156
            |.:||||:..:...:.:.|...|.:.:....|::.. .:..|:...||.||..|:...:|::...
Human   144 LSIANRLYGEQEFPICQEYLDGVIQFYHTTIESVDFQKNPEKSRQEINFWVECQSQGKIKELFSK 208

  Fly   157 SDLTPDESAVMINAAFFKGYWKTRFDKMNTKPKVFYVSKSYQVNVNMMSQVGRFKMRTSTID--- 218
            ..:..:...|::||.:||..|:|.||..||....|.::.:...:|.||:|.|.:  |...|:
Human   209 DAINAETVLVLVNAVYFKAKWETYFDHENTVDAPFCLNANENKSVKMMTQKGLY--RIGFIEEVK 271

  Fly   219 -QIIELPFAYSNLSMVIVLP---KDN-GSLTQAEATIESYPQIV-------LTEMDVHVQLPKFK 271
             ||:|:.:....|||.::||   ||| ..|.:.|..| :|.::|       ::|..|.:..|:|.
Human   272 AQILEMRYTKGKLSMFVLLPSHSKDNLKGLEELERKI-TYEKMVAWSSSENMSEESVVLSFPRFT 335

  Fly   272 IDFRMELVETLKSMGIQDLFNSS-SDISVLLNQSGTRISQVVHKAFIEIDEEGGSAGSASASPI- 334
            ::...:|...|:.|||.|:|:.: :|::.:.......:|:::||.|:|:||.|..|.:|:.:.:
Human   336 LEDSYDLNSILQDMGITDIFDETRADLTGISPSPNLYLSKIIHKTFVEVDENGTQAAAATGAVVS 400

  Fly   335 -RGLSDYATSVVTFTVNSPFVFMIRDD--DNIYFRGRVVDP 372
             |.|..:    |.|..|.||:|.||.:  ..|.|.|||..|
Human   401 ERSLRSW----VEFNANHPFLFFIRHNKTQTILFYGRVCSP 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Da	NP_001036345.1	SERPIN	16..369	CDD:238101	107/418 (26%)
SERPINB12	XP_005266835.2	ovalbumin_like	16..437	CDD:239014	112/429 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	221	1.000	Domainoid score	I2614
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	222	1.000	Inparanoid score	I3541
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.980