DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Da and SERPINH1

DIOPT Version :9

Sequence 1:	NP_001036345.1	Gene:	Spn28Da / 34082	FlyBaseID:	FBgn0051902	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_001193943.1	Gene:	SERPINH1 / 871	HGNCID:	1546	Length:	418	Species:	Homo sapiens

Alignment Length:	363	Identity:	85/363 - (23%)
Similarity:	172/363 - (47%)	Gaps:	18/363 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LYRSFLQDNKQYNIIASPLCVEIGMSMILMGADGNTANELRTALNLPE--DKKNVATIYDKLLTK 83
            ||::..:|....||:.||:.|...:.::.:|....||::.:..|:..:  |::..|.:.:.|.:.
Human    54 LYQAMAKDQAVENILVSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSL 118

  Fly    84 LERGKKVAILHLANRLFVNETIGVNKRYNKLVNKHFRAEAEAIKLADRLKAAWAINDWVLDQTLD 148
            .....:.....|.:||:...::.....:.:...:|:..|...|...|:..|..:||:|....|..
Human   119 SNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDG 183

  Fly   149 NVKDIIIPSDLTPDESAVMINAAFFKGYWKTRFDKMNTKPKVFYVSKSYQVNVNMMSQVGRFKMR 213
            .:.:  :..|:...:.|:::||.|||.:|..:|.......:.|.|::||.|.|.||.:.|.:...
Human   184 KLPE--VTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVMMMHRTGLYNYY 246

  Fly   214 TSTID--QIIELPFAYSNLSMVIVLPKDNGSLTQAEATI-ESYPQIVLTEMD---VHVQLPKFKI 272
            ....:  ||:|:|.|:...|::|::|.....|.:.|..: :...:|.:.:|.   |.:.|||..:
Human   247 DDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVV 311

  Fly   273 DFRMELVETLKSMGIQDLFN-SSSDISVLLNQSGTRISQVVHKAFIEIDEEGGSAGSASASPIRG 336
            :...:|.:.|..:|:.:..: :.:|:|.:..:....::.|.|....|:|.:    |:.....|.|
Human   312 EVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFELDTD----GNPFDQDIYG 372

  Fly   337 LSDYATSVVTFTVNSPFVFMIRD--DDNIYFRGRVVDP 372
            ..: ..|...|..:.||:|::||  ..::.|.||:|.|
Human   373 REE-LRSPKLFYADHPFIFLVRDTQSGSLLFIGRLVRP 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Da	NP_001036345.1	SERPIN	16..369	CDD:238101	82/358 (23%)
SERPINH1	NP_001193943.1	serpinH1_CBP1	36..417	CDD:381003	85/363 (23%)
SERPINH1	NP_001193943.1	Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	415..418
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920