DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Da and Serpind1

DIOPT Version :9

Sequence 1:	NP_001036345.1	Gene:	Spn28Da / 34082	FlyBaseID:	FBgn0051902	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_077358.1	Gene:	Serpind1 / 79224	RGDID:	619854	Length:	479	Species:	Rattus norvegicus

Alignment Length:	387	Identity:	109/387 - (28%)
Similarity:	180/387 - (46%)	Gaps:	48/387 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 QFTKQLYRSFLQD--NKQYNIIASPLCVEIGMSMILMGADGNTANELRTALNLPE-----DKKNV 73
            :|...||| .|:|  ....||..:|:.:...|.||.:|..|.|..|:.:.|:..:     .|..|
  Rat   112 KFAFNLYR-VLKDQATSSDNIFIAPVGISTAMGMISLGLRGETHEEVHSVLHFKDFVNASSKYEV 175

  Fly    74 ATIYD---KLLTKLERGKKVAILHLANRLFVNETIGVNKRYNKLVNKHFRAEAEAIKLADRLKAA 135
            .||::   ||..:|.|......|...|.|::.:...:.:.:...:.:.:.|||:....:|....:
  Rat   176 TTIHNLFRKLTHRLFRRNFGYTLQSVNDLYIQKQFPIREDFKAAMREFYFAEAQEADFSDPAFIS 240

  Fly   136 WAINDWVLDQTLDNVKDIIIPSDLTPDESAVMINAAFFKGYWKTRFDKMNTKPKVFYVSKSYQVN 200
            .| |..:|..|...:|:.:..:|..  ...:::|..:|||.|..:|....|....|.:::...|.
  Rat   241 KA-NSHILKLTKGLIKEALENTDSA--TQMMILNCIYFKGAWMNKFPVEMTHNHNFRLNEREVVK 302

  Fly   201 VNMMSQVGRFKMRTSTIDQ-----IIELPFAYSNLSMVIVLPKDNGSLTQAEATIESYPQIV--- 257
            |:||...|.|   .:..||     |::|.:. ..:||:||:|:....:...||.:.  ||:|
  Rat   303 VSMMQTKGNF---LAANDQELDCDILQLEYV-GGISMLIVIPRKLSGMKTLEAQLT--PQVVERW 361

  Fly   258 ---LTEMDVHVQLPKFKIDFRMELVETLKSMGIQDLFNSSSDISVLLNQSGTRISQVV-----HK 314
               :|.....|.|||||::....|||.||||||..|||.:.      |.||....:::     |:
  Rat   362 QKSMTNRTREVLLPKFKLEKNYNLVEVLKSMGITKLFNKNG------NMSGISDQRIIIDLFKHQ 420

  Fly   315 AFIEIDEEGGSAGSASASPIRGLSDYATSVVTFTVNSPFVFMIRDDDN--IYFRGRVVDPLK 374
            :.|.::|||..|.:.:......||    :.|.|||:.||:|::.:...  :.|.|||.:|.|
  Rat   421 STITVNEEGTQAAAVTTVGFMPLS----TQVRFTVDRPFLFLVYEHRTSCLLFMGRVANPAK 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Da	NP_001036345.1	SERPIN	16..369	CDD:238101	105/380 (28%)
Serpind1	NP_077358.1	HCII	44..477	CDD:239002	107/384 (28%)
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	55..79
		Glycosaminoglycan-binding site. /evidence=ECO:0000250	172..192		7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020