DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Da and SERPINA7

DIOPT Version :9

Sequence 1:	NP_001036345.1	Gene:	Spn28Da / 34082	FlyBaseID:	FBgn0051902	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	XP_006724746.1	Gene:	SERPINA7 / 6906	HGNCID:	11583	Length:	425	Species:	Homo sapiens

Alignment Length:	393	Identity:	106/393 - (26%)
Similarity:	178/393 - (45%)	Gaps:	44/393 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TSVLGQFTKQLYRSFLQDNKQYNIIASPLCVEIGMSMILMGADGNTANELRTAL--NLPEDKK-N 72
            :|:...|...|||.|..:....||..||:.:...:.|:..||..:|..|:...|  ||.:... .
Human    43 SSINADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGFNLTDTPMVE 107

  Fly    73 VATIYDKLLTKLERGKKVAILHLANRLFVNETIGVNKRYNKLVNKHFRAEAEAIKLADRLKAAWA 137
            :...:..|:..|...||...|.:.|.||:.:.:....::...|...:..|..:...::...|...
Human   108 IQHGFQHLICSLNFPKKELELQIGNALFIGKHLKPLAKFLNDVKTLYETEVFSTDFSNISAAKQE 172

  Fly   138 INDWVLDQTLDNVKDIIIPSDLTPDESAVMINAAFFKGYWKTRFDKMNTK-PKVFYVSKSYQVNV 201
            ||..|..||...|..:|  .||.|:...|::|...||..|...||...|: ...|.:.|:..|.|
Human   173 INSHVEMQTKGKVVGLI--QDLKPNTIMVLVNYIHFKAQWANPFDPSKTEDSSSFLIDKTTTVQV 235

  Fly   202 NMMSQVGRFKMRTSTIDQ-----IIELPFAYSNLSMVIVLPKDNGSLTQAEA-----TIESYPQI 256
            .||.|:.::   ...:|.     ::::.::.:.|:: .||||: |.:...||     |::.:.::
Human   236 PMMHQMEQY---YHLVDMELNCTVLQMDYSKNALAL-FVLPKE-GQMESVEAAMSSKTLKKWNRL 295

  Fly   257 VLTEMDVHVQLPKFKIDFRMELVETLKSMGIQDLFNSSSDISVLLNQSGTRIS----------QV 311
             |.:..|.:.:|||.|....:|..||..||||..::.::|.|.|...:|.::|          |.
Human   296 -LQKGWVDLFVPKFSISATYDLGATLLKMGIQHAYSENADFSGLTEDNGLKLSNRPAGFVLPTQA 359

  Fly   312 VHKAFIEIDEEGGSAGSASASPIRGLSDYATSVVTF-----TVNSPFVFMI--RDDDNIYFRGRV 369
            .|||.:.|.|:|   ..|:|.|...|||...:  ||     .::..|:.:|  |...:|.|.|:|
Human   360 AHKAVLHIGEKG---TEAAAVPEVELSDQPEN--TFLHPIIQIDRSFMLLILERSTRSILFLGKV 419

  Fly   370 VDP 372
            |:|
Human   420 VNP 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Da	NP_001036345.1	SERPIN	16..369	CDD:238101	102/383 (27%)
SERPINA7	XP_006724746.1	alpha-1-antitrypsin_like	46..419	CDD:239011	102/385 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010