Protein Alignment Spn28Da and SERPINB3

DIOPT Version :10

• Sequence 1: NP_001036345.1
• Gene: Spn28Da / 34082
• FlyBaseID: FBgn0051902
• Length: 384
• Species: Drosophila melanogaster
• Sequence 2: NP_008850.1
• Gene: SERPINB3 / 6317
• HGNCID: 10569
• Length: 390
• Species: Homo sapiens
• Alignment Length: 391
• Identity: 120/391 - (30%)
• Similarity: 209/391 - (53%)
• Gaps: 44/391 - (11%)

  Fly    16 QFTKQLYRSFLQDNKQYNIIASPLCVEIGMSMILMGADGNTANELRTALNLPE------------ 68
            :|...|::.| :.:|:.||..||:.:...:.|:|:||..|||.:::..|:..:
Human    10 KFMFDLFQQF-RKSKENNIFYSPISITSALGMVLLGAKDNTAQQIKKVLHFDQVTENTTGKAATY 73

  Fly    69 --DKK-NVATIYDKLLTKLERGKKVAILHLANRLFVNETIGVNKRYNKLVNKHFRAEAEAIKLAD 130
              |:. ||...:.||||:..:......|.:||:||..:|....:.|...:.|.::...|::..|:
Human    74 HVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYLFLQEYLDAIKKFYQTSVESVDFAN 138

  Fly   131 -----RLKAAWAINDWVLDQTLDNVKDIIIPSDLTPDESAVMINAAFFKGYWKTRFDKMNTKPKV 190
                 |.|    ||.||..||.:.:|::|...::..:.:.|::||.:|||.|:.:|:|.:||.:.
Human   139 APEESRKK----INSWVESQTNEKIKNLIPEGNIGSNTTLVLVNAIYFKGQWEKKFNKEDTKEEK 199

  Fly   191 FYVSKSYQVNVNMMSQVGRFKMRTSTID---QIIELPFAYSNLSMVIVLPKDNGSLTQ------A 246
            |:.:|:...::.||.|...|.. .|..|   :::|:|:...:|||:::||.:...|.:      |
Human   200 FWPNKNTYKSIQMMRQYTSFHF-ASLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQKLEEKLTA 263

  Fly   247 EATIE--SYPQIVLTEMDVHVQLPKFKIDFRMELVETLKSMGIQDLFNSSSDISVLLNQSGTRIS 309
            |..:|  |...:..|.:|:|  ||:||::...:|.:||::||:.|:||..:|:|.:....|..:|
Human   264 EKLMEWTSLQNMRETRVDLH--LPRFKVEESYDLKDTLRTMGMVDIFNGDADLSGMTGSRGLVLS 326

  Fly   310 QVVHKAFIEIDEEGGSAGSASASPIRGLSDYATSV-VTFTVNSPFVFMIRDD--DNIYFRGRVVD 371
            .|:||||:|:.|||..|.:|:|  :.|.....||. ..|..|.||:|.||.:  ::|.|.||...
Human   327 GVLHKAFVEVTEEGAEAAAATA--VVGFGSSPTSTNEEFHCNHPFLFFIRQNKTNSILFYGRFSS 389

  Fly   372 P 372
            |
Human   390 P 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Da	NP_001036345.1	serpin42Dd-like_insects	12..372	CDD:381070	119/389 (31%)
SERPINB3	NP_008850.1	serpinB3_B4_SCCA1_2	1..390	CDD:381030	119/389 (31%)