DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Da and Serpinb2

DIOPT Version :9

Sequence 1:	NP_001036345.1	Gene:	Spn28Da / 34082	FlyBaseID:	FBgn0051902	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_067728.1	Gene:	Serpinb2 / 60325	RGDID:	621823	Length:	416	Species:	Rattus norvegicus

Alignment Length:	413	Identity:	108/413 - (26%)
Similarity:	185/413 - (44%)	Gaps:	64/413 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FTKQLYRSFLQDNKQYNIIASPLCVEIGMSMILMGADGNTANELRTALNL------------PE- 68
            |...|.:...|.|...||..||..:...::::.:||..||..::...||.            ||
  Rat    11 FALNLLKQIEQSNSTQNIFISPWSISSTLAIVFLGAQANTEEQMAKVLNFDKIGSYDLTPGNPEN 75

  Fly    69 ------------DKKNVATIY----DKL------LTKLERGKKVA--ILHLANRLFVNETIGVNK 109
                        |...||.:.    ||:      |:......::.  :|..||:||..::....:
  Rat    76 FHGCDFAQHIQRDNYPVAILQAQARDKIHSAFSSLSSTINTPRLGDYLLESANKLFGEKSARFKE 140

  Fly   110 RYNKLVNKHFRAEAEAIKLAD-RLKAAWAINDWVLDQTLDNVKDIIIPSDLTPDESAVMINAAFF 173
            .|.:...|::..|.||:...: ..:|...||.||..||...:.:::....:..|...|::|..:|
  Rat   141 EYIQRCKKYYSTEPEAVDFLECANEARKKINSWVKTQTKGEIPNLLPEGSVDEDTKMVLVNTIYF 205

  Fly   174 KGYWKTRFDKMNTKPKVFYVSKSYQVNVNMM-----SQVGRFK-MRTSTIDQIIELPFAYSNLSM 232
            ||.|||.|.|.......|.|:.:....|.||     ..:|..| ::|    ||:|||: ..|:||
  Rat   206 KGRWKTPFQKRLNGLYPFRVNLNESKPVQMMYLREKLNIGYIKDLKT----QILELPY-IGNISM 265

  Fly   233 VIVLP---KDNGS---LTQAEATIESYPQIV----LTEMDVHVQLPKFKIDFRMELVETLKSMGI 287
            .::||   :|:.:   :.:.|...:::.:.:    |.|.||.|.:||||:....||...|:.||:
  Rat   266 FLLLPDEIEDSSTGLEMLEREINFDNFNKWISKETLDEDDVLVYIPKFKLAQNYELKPILQRMGM 330

  Fly   288 QDLFN-SSSDISVLLNQSGTRISQVVHKAFIEIDEEGGSAGSASASPIRGLSDYATSVVTFTVNS 351
            :|.|| ..:|.|.:...:...:|:|.|:|.::::|||..|...:.:.:.|.:.:...  .|..:.
  Rat   331 EDAFNKGKADFSGMSESNDLFLSEVFHQATVDVNEEGTVAAGGTGAVMTGRTGHGGP--QFVADH 393

  Fly   352 PFVFMIRDD--DNIYFRGRVVDP 372
            ||:|.|.::  ..|.|.||...|
  Rat   394 PFLFFIMNNITRTILFVGRFSSP 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Da	NP_001036345.1	SERPIN	16..369	CDD:238101	106/408 (26%)
Serpinb2	NP_067728.1	serpinB2_PAI-2	2..416	CDD:381029	107/411 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.930