DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Da and SERPINA1

DIOPT Version :9

Sequence 1:	NP_001036345.1	Gene:	Spn28Da / 34082	FlyBaseID:	FBgn0051902	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_000286.3	Gene:	SERPINA1 / 5265	HGNCID:	8941	Length:	418	Species:	Homo sapiens

Alignment Length:	380	Identity:	104/380 - (27%)
Similarity:	182/380 - (47%)	Gaps:	27/380 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TSVLGQFTKQLYRSFLQDNKQYNIIASPLCVEIGMSMILMGADGNTANELRTALN-----LPEDK 70
            |..|.:|...|||.....:...||..||:.:....:|:.:|...:|.:|:...||     :||
Human    51 TPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPE-- 113

  Fly    71 KNVATIYD---KLLTKLERGKKVAILHLANRLFVNETIGVNKRYNKLVNKHFRAEAEAIKLADRL 132
               |.|::   :||..|.:......|...|.||::|.:.:..::.:.|.|.:.:||..:...|..
Human   114 ---AQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTE 175

  Fly   133 KAAWAINDWVLDQTLDNVKDIIIPSDLTPDESAVMINAAFFKGYWKTRFDKMNTKPKVFYVSKSY 197
            :|...|||:|...|...:.|::  .:|..|....::|..||||.|:..|:..:|:.:.|:|.:..
Human   176 EAKKQINDYVEKGTQGKIVDLV--KELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVT 238

  Fly   198 QVNVNMMSQVGRFKMR-TSTIDQIIELPFAYSNLSMVIVLPKDNGSL--TQAEATIESYPQIVLT 259
            .|.|.||.::|.|.:: ...:...:.|.....|.:.:..|| |.|.|  .:.|.|.:...:.:..
Human   239 TVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLP-DEGKLQHLENELTHDIITKFLEN 302

  Fly   260 E--MDVHVQLPKFKIDFRMELVETLKSMGIQDLFNSSSDISVLLNQSGTRISQVVHKAFIEIDEE 322
            |  ....:.|||..|....:|...|..:||..:|::.:|:|.:..::..::|:.||||.:.|||:
Human   303 EDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEK 367

  Fly   323 GGSAGSASASPIRGLSDYATSVVTFTVNSPFVFMI--RDDDNIYFRGRVVDPLKK 375
            |..|  |.|..:..:.......|.|  |.||||::  ::..:..|.|:||:|.:|
Human   368 GTEA--AGAMFLEAIPMSIPPEVKF--NKPFVFLMIEQNTKSPLFMGKVVNPTQK 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Da	NP_001036345.1	SERPIN	16..369	CDD:238101	98/367 (27%)
SERPINA1	NP_000286.3	alpha-1-antitrypsin_like	55..412	CDD:239011	98/368 (27%)
SERPINA1	NP_000286.3	RCL	368..392		6/27 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010