DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Da and SERPINB2

DIOPT Version :9

Sequence 1:	NP_001036345.1	Gene:	Spn28Da / 34082	FlyBaseID:	FBgn0051902	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_001137290.1	Gene:	SERPINB2 / 5055	HGNCID:	8584	Length:	415	Species:	Homo sapiens

Alignment Length:	410	Identity:	101/410 - (24%)
Similarity:	188/410 - (45%)	Gaps:	59/410 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FTKQLYRSFLQDNKQYNIIASPLCVEIGMSMILMGADGNTANELRTALNLPEDKKNVAT------ 75
            |...|::...:.:...|:..||..:...|:|:.||:.|:|.:::...|...|...|..|
Human    11 FALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQFNEVGANAVTPMTPEN 75

  Fly    76 -------------IYDKLLTKLERGKKV-----------------AILHLANRLFVNETIGVNKR 110
                         .|...:.:.:...|:                 .:|...|:||..::....:.
Human    76 FTSCGFMQQIQKGSYPDAILQAQAADKIHSSFRSLSSAINASTGNYLLESVNKLFGEKSASFREE 140

  Fly   111 YNKLVNKHFRAEAEAIKLAD-RLKAAWAINDWVLDQTLDNVKDIIIPSDLTPDESAVMINAAFFK 174
            |.:|..|::.:|.:|:...: ..:|...||.||..||...:.:::....:..|...|::||.:||
Human   141 YIRLCQKYYSSEPQAVDFLECAEEARKKINSWVKTQTKGKIPNLLPEGSVDGDTRMVLVNAVYFK 205

  Fly   175 GYWKTRFDKMNTKPKVFYVSKSYQVNVNMMSQVGRFKMRTSTID----QIIELPFAYSNLSMVIV 235
            |.|||.|:|.......|.|:.:.:..|.||..  |.|:....|:    ||:|||:| .::||.::
Human   206 GKWKTPFEKKLNGLYPFRVNSAQRTPVQMMYL--REKLNIGYIEDLKAQILELPYA-GDVSMFLL 267

  Fly   236 LPKDNGSLTQAEATIES---YPQI-------VLTEMDVHVQLPKFKIDFRMELVETLKSMGIQDL 290
            ||.:...::.....:||   |.::       .:.|.:|.|.:|:||::...||...|:|||::|.
Human   268 LPDEIADVSTGLELLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKLEEHYELRSILRSMGMEDA 332

  Fly   291 FNSS-SDISVLLNQSGTRISQVVHKAFIEIDEEGGSAGSASASPIRGLSDYATSVVTFTVNSPFV 354
            ||.. ::.|.:..::...:|:|.|:|.::::|||..|.:.:...:.|.:.:...  .|..:.||:
Human   333 FNKGRANFSGMSERNDLFLSEVFHQAMVDVNEEGTEAAAGTGGVMTGRTGHGGP--QFVADHPFL 395

  Fly   355 FMI--RDDDNIYFRGRVVDP 372
            |:|  :..:.|.|.||...|
Human   396 FLIMHKITNCILFFGRFSSP 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Da	NP_001036345.1	SERPIN	16..369	CDD:238101	99/405 (24%)
SERPINB2	NP_001137290.1	PAI-2	4..415	CDD:239013	100/408 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.930