DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Da and SERPINE1

DIOPT Version :9

Sequence 1:	NP_001036345.1	Gene:	Spn28Da / 34082	FlyBaseID:	FBgn0051902	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_001373389.1	Gene:	SERPINE1 / 5054	HGNCID:	8583	Length:	492	Species:	Homo sapiens

Alignment Length:	386	Identity:	89/386 - (23%)
Similarity:	179/386 - (46%)	Gaps:	40/386 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CWILVTTSVLGQ-----------------FTKQLYRSFLQDNKQYNIIASPLCVEIGMSMILMGA 52
            |.:|....|.|:                 |..::::...|.:|..|::.||..|...::|:.:..
Human     9 CLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTT 73

  Fly    53 DGNTANELRTALNLPEDKKNVAT----IYDKLLTKLERGKKVAILHLANRLFVNETIGVNKRYNK 113
            .|.|..:::.|:....|.|.:|.    :|.:|:....:.:    :...:.:||...:.:.:.:..
Human    74 GGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDE----ISTTDAIFVQRDLKLVQGFMP 134

  Fly   114 LVNKHFRAEAEAIKLADRLKAAWAINDWVLDQTLDNVKDIIIPSDLTPDESAVMINAAFFKGYWK 178
            ...:.||:..:.:..::..:|.:.|||||...|...:.:::....:......|::||.:|.|.||
Human   135 HFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWK 199

  Fly   179 TRFDKMNTKPKVFYVSKSYQVNVNMMSQVGRFKMRTSTID-----QIIELPFAYSNLSMVIVLPK 238
            |.|...:|..::|:.|....|:|.||:|..:|.....|..     .|:|||:....|||.|..|.
Human   200 TPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPY 264

  Fly   239 DN----GSLTQ-AEATIESYPQIVLTEMDVHVQLPKFKIDFRMELVETLKSMGIQDLFNS-SSDI 297
            :.    .:||. ..|.:.|:.:..:|.:...:.||||.::..::|.:.|:::|:.|:|.. .:|.
Human   265 EKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADF 329

  Fly   298 SVLLNQSGTRISQVVHKAFIEIDEEGGSAGSASASPIRGLSDYATSVVTFTVNSPFVFMIR 358
            :.|.:|....::|.:.|..||::|.|..|.|::|..:..    ..:.....::.||:|::|
Human   330 TSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSA----RMAPEEIIMDRPFLFVVR 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Da	NP_001036345.1	SERPIN	16..369	CDD:238101	85/375 (23%)
SERPINE1	NP_001373389.1	serpinE1_PAI-1	29..393	CDD:381007	85/366 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020