DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Da and serpine2

DIOPT Version :9

Sequence 1:	NP_001036345.1	Gene:	Spn28Da / 34082	FlyBaseID:	FBgn0051902	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_956478.1	Gene:	serpine2 / 393153	ZFINID:	ZDB-GENE-040426-848	Length:	395	Species:	Danio rerio

Alignment Length:	399	Identity:	123/399 - (30%)
Similarity:	205/399 - (51%)	Gaps:	46/399 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LCWILVTTSVLGQFTK-------QLYRSFLQDNKQYNIIASPLCVEIGMSMILMGADGNTANELR 61
            ||.:.|:.|....:..       |::...|||..|.|::.||..|...:.|:|.||.|:|..:|
Zfish    13 LCSVSVSQSQSSSYGARGSDLGLQVFMQVLQDRAQENVLLSPHGVASVLGMLLPGAHGDTRRQL- 76

  Fly    62 TALNLPEDKKNVATIYDKLLTKLERG----KKVAILHLANRLFVNETIGVNKRYNKLVNKHFRAE 122
              ||..:.|||...   |:|.||.:.    ....|:.:||.||.||...:.:.:.....::|..|
Zfish    77 --LNGLKYKKNGPY---KMLRKLHKSLTTKSNADIVTIANALFPNEGFSMKEDFLSANRENFLCE 136

  Fly   123 AEAIKLADRLKAAWAINDWVLDQTLDNVKDIIIPSDLTPD--ESA----VMINAAFFKGYWKTRF 181
            :.::..:|...||.:|||||.:.|...     |||.:|.|  ::|    |.:|:.||||.||:||
Zfish   137 SHSVDYSDPEAAAQSINDWVKNSTKGQ-----IPSVVTADMFDTALTRLVAVNSIFFKGLWKSRF 196

  Fly   182 DKMNTKPKVFYVSKSYQVNVNMMSQVGRFKM-RTSTIDQ----IIELPFAYSNLSMVIVLP-KDN 240
            ...:|||:.|.........|.||||:..|.| :.||.|.    :||||:..:::||.|.|| :|:
Zfish   197 QPQSTKPRSFTAGDGNTYKVPMMSQLSVFNMGQASTPDGQKYIVIELPYHGNSMSMFIALPTEDS 261

  Fly   241 GSLTQ-----AEATIESYPQIVLTEMDVHVQLPKFKIDFRMELVETLKSMGIQDLFNSSSDISVL 300
            ..|:.     :..||:|:.:: :....:.:.:|||.::..::|...||::||:|:|:.:......
Zfish   262 TPLSSILPHISTNTIQSWTKL-MNPRRMRLLMPKFTVEQELDLETPLKALGIKDIFDQNKADFRH 325

  Fly   301 LNQSGTRISQVVHKAFIEIDEEGGSAGSASASPIRGLSDYATSVVTFTVNSPFVFMIRDDDN--I 363
            |:.....:|:.:.||.||::|:|..|.:.::..:...|    |....||:.||:|:||.:.:  |
Zfish   326 LSSESIYVSKALQKAKIEVNEDGTKASATTSVILHARS----SPPWVTVDRPFLFLIRHNSSGTI 386

  Fly   364 YFRGRVVDP 372
            .|.|::..|
Zfish   387 LFAGQINKP 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Da	NP_001036345.1	SERPIN	16..369	CDD:238101	118/382 (31%)
serpine2	NP_956478.1	PAI-1_nexin-1	26..395	CDD:239006	118/384 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.030