DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Da and Serpinb1b

DIOPT Version :9

Sequence 1:	NP_001036345.1	Gene:	Spn28Da / 34082	FlyBaseID:	FBgn0051902	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	XP_038952280.1	Gene:	Serpinb1b / 306891	RGDID:	1560658	Length:	380	Species:	Rattus norvegicus

Alignment Length:	389	Identity:	120/389 - (30%)
Similarity:	193/389 - (49%)	Gaps:	52/389 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FTKQLYRSFLQDNKQYNIIASPLCVEIGMSMILMGADGNTA-NELRTALNLPEDK-KNVATIYDK 79
            |..:|:.:..:.:...||. ||..:...::|:.:||.|::| :.||.|.....|. :::.:.:..
  Rat    11 FALELFHTLSESSPTGNIF-SPFSISSALAMVFLGAKGSSAPSSLRLAETFHFDSVEDIHSRFQS 74

  Fly    80 LLTKLERGKKVAILHLANRLFVNETIGVNKRYNKLVNKHFRAEAEAIKLADRL---------KAA 135
            |..::.:......|.:||||:..:|      ||.|  ..|.|..:.:..||..         .|.
  Rat    75 LNAEMRKHGASHTLKVANRLYGEKT------YNFL--PEFLASTQKMYGADLAPVDFQHASEDAR 131

  Fly   136 WAINDWVLDQTLDNVKDIIIPSDLTPDESAVMINAAFFKGYWKTRFDKMNTKPKVFYVSKSYQVN 200
            ..||.||..||...:.:::....:......|::||.:|||.|:.:|...:|....|.::|.....
  Rat   132 KEINKWVKGQTEGKIPELLAGGVVNSTTKLVLVNAIYFKGIWQEKFLTRHTTDAPFRLNKKDTKM 196

  Fly   201 VNMMSQVGRF--------KMRTSTIDQIIELPFAYSNLSMVIVLPKD----NGSLTQAE--ATIE 251
            |.||.|..:|        |.:      ::|:|:....|||||:||:|    :..|.:.|  .|:|
  Rat   197 VKMMYQKEKFPFGYIPDLKCK------VLEMPYQGGELSMVILLPEDIEDESTGLQKIEEQLTLE 255

  Fly   252 SYPQIV----LTEMDVHVQLPKFKIDFRMELVETLKSMGIQDLFNSS-SDISVLLNQSGTRISQV 311
            ...:..    |.|:||||.||||||:....|...|..:|:||||:|| :|:|.:.......||::
  Rat   256 KLYEWTKHENLKEIDVHVNLPKFKIEESYILNSNLGRLGLQDLFSSSKADLSGMSESRDIFISKI 320

  Fly   312 VHKAFIEIDEEGGSAGSASASPIRGLSDYA-TSVVTFTVNSPFVFMIRDDD--NIYFRGRVVDP 372
            |||:|:|::|||..|.:|:|    ||.:|. .|:..|.|:.||:|.||.:.  |:.|.|||..|
  Rat   321 VHKSFVEVNEEGTEAAAATA----GLVEYCLVSIEAFIVDHPFLFFIRHNPTANMLFFGRVCSP 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Da	NP_001036345.1	SERPIN	16..369	CDD:238101	117/384 (30%)
Serpinb1b	XP_038952280.1	serpinB1_LEI	1..380	CDD:381028	119/387 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.930