DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Da and Serpinb10

DIOPT Version :9

Sequence 1:	NP_001036345.1	Gene:	Spn28Da / 34082	FlyBaseID:	FBgn0051902	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_714955.2	Gene:	Serpinb10 / 266775	RGDID:	628853	Length:	397	Species:	Rattus norvegicus

Alignment Length:	398	Identity:	97/398 - (24%)
Similarity:	195/398 - (48%)	Gaps:	47/398 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LGQFTKQLYRSFLQDNKQYNIIASPLCVEIGMSMILMGADGNTANELRTALNL---------PED 69
            :.||..:..:...:..:..||..||..:...::|:.:|..|.||.::...|:.         |:.
  Rat     8 INQFAVEFSKKLAESAEGRNIFFSPWGISTSLAMVYLGTKGTTAAQMSQVLHFGSIQDFKFGPDS 72

  Fly    70 KK------------NVATIYDKLLTKLERGKKVAILHLANRLFVNETIGVNKRYNKLVNKHFRAE 122
            :|            .:.:.:..|..|:.:.....:|.:|||::|.:|...:.:|.:.:..:|.||
  Rat    73 EKKRKMECHSGKSEEIQSDFQTLTAKILKHGNSYVLKIANRIYVEKTYLFHNKYLEDMKTYFGAE 137

  Fly   123 AEAIKLADRL-KAAWAINDWVLDQTLDNVKDIIIPSDLTPDESA-VMINAAFFKGYWKTRFDKMN 185
            .:::...:.. :....||.||..||...:.: ::|.|...:::. |::||.:|||.|:.:|...|
  Rat   138 PQSVNFVEASGQIRKEINSWVGSQTGGKIPN-LLPDDAVDNKTTMVLVNALYFKGTWEHQFSVQN 201

  Fly   186 TKPKVFYVSKSYQVNVNMMSQVGRFKMRTSTIDQI----IELPFAYSNLSMVIVLPKDNGSLTQA 246
            |..:.|.::|:....|.|||.  :..::...|:::    ::|.:.....|::::||::...|.|.
  Rat   202 TTERPFRINKTTSKPVQMMSM--KQSLQVFHIEELQTIGVQLHYQNREFSLLLLLPEEVEGLKQL 264

  Fly   247 EATIESYPQI-------VLTEMDVHVQLPKFKIDFRMELVETLKSMGIQDLFN-SSSDISVLLNQ 303
            |..| :|.::       ::...:|.:.|||||::...:|...|:.||:.|.|| ..::.|.:.::
  Rat   265 ERAI-TYEKLDKWTSADMMDTYEVQLYLPKFKMEESYDLQSALRDMGMTDAFNQGKANFSNMTSE 328

  Fly   304 SGTRISQVVHKAFIEIDEEGGSAGSASASPIRGLSDYATSVVTFTVNS--PFVFMIRDD--DNIY 364
            ....:|.|.||.|:||:|||..|.:.:.|.:    ::.....:..:|:  ||:|:||.:  :.|.
  Rat   329 RNLFLSNVFHKTFLEINEEGTEAAAGTGSEV----NFRIKAPSIELNADHPFLFLIRHNVTNTIL 389

  Fly   365 FRGRVVDP 372
            |.||...|
  Rat   390 FYGRFYSP 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Da	NP_001036345.1	SERPIN	16..369	CDD:238101	95/391 (24%)
Serpinb10	NP_714955.2	SERPIN	4..397	CDD:294093	96/396 (24%)
Serpinb10	NP_714955.2	Nuclear localization signal. /evidence=ECO:0000250	74..77		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.830