DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Da and SERPINA11

DIOPT Version :9

Sequence 1:	NP_001036345.1	Gene:	Spn28Da / 34082	FlyBaseID:	FBgn0051902	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_001073920.1	Gene:	SERPINA11 / 256394	HGNCID:	19193	Length:	422	Species:	Homo sapiens

Alignment Length:	382	Identity:	103/382 - (26%)
Similarity:	181/382 - (47%)	Gaps:	31/382 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TSVLGQFTKQLYRSFLQDNKQYNIIASPLCVEIGMSMILMGADGNTANELRTAL--NLPE-DKKN 72
            |..:..|..:||:....| ...||..||:.:...::::.:||..||:..:...|  ||.| .:.:
Human    51 TPTITNFALRLYKELAAD-APGNIFFSPVSISTTLALLSLGAQANTSALILEGLGFNLTETPEAD 114

  Fly    73 VATIYDKLLTKLERGKKVAILHLANRLFVNETIGVNKRYNKLVNKHFRAEAEAIKLADRLKAAWA 137
            :...:..||..|........|.:.|.||:::.:...:.|...:.:.:.|.|.:....|.:.....
Human   115 IHQGFRSLLHTLALPSPKLELKVGNSLFLDKRLKPRQHYLDSIKELYGAFAFSANFTDSVTTGRQ 179

  Fly   138 INDWVLDQTLDNVKDIIIPSDLTPDESAVMINAAFFKGYWKTRFDKMNT-KPKVFYVSKSYQVNV 201
            |||::..||...|.|.:  .:.:.|...|:.|..|||..||..|.:..| |.:.|:|.:...:.|
Human   180 INDYLRRQTYGQVVDCL--PEFSQDTFMVLANYIFFKAKWKHPFSRYQTQKQESFFVDERTSLQV 242

  Fly   202 NMMSQ--VGRFKMRTSTIDQIIELPFAYSNLSMVIVLPKDNGSLTQAEA-----TIESYPQIVLT 259
            .||.|  :.||.........::::.:. .|...::||| |.|.:.|.||     |:..:.|::|.
Human   243 PMMHQKEMHRFLYDQDLACTVLQIEYR-GNALALLVLP-DPGKMKQVEAALQPQTLRKWGQLLLP 305

  Fly   260 E-MDVHVQLPKFKIDFRMELVETLKSMGIQDLFNSSSDISVLLNQSGTRISQVVHKAFIEIDEEG 323
            . :|:|  ||:|.|.....|.:.|..:|:.::.|..:|.|.:..|....||:|.|||.:::.|:|
Human   306 SLLDLH--LPRFSISGTYNLEDILPQIGLTNILNLEADFSGVTGQLNKTISKVSHKAMVDMSEKG 368

  Fly   324 GSAGSASASPIRGLSDYATSVVTFT-----VNSPFVFMIRD--DDNIYFRGRVVDPL 373
            ..||:||     ||.....|:.|.:     .|.||:.::.:  ..::.|.|:||:|:
Human   369 TEAGAAS-----GLLSQPPSLNTMSDPHAHFNRPFLLLLWEVTTQSLLFLGKVVNPV 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Da	NP_001036345.1	SERPIN	16..369	CDD:238101	99/371 (27%)
SERPINA11	NP_001073920.1	alpha-1-antitrypsin_like	53..416	CDD:239011	99/374 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010