DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Da and Serpina1b

DIOPT Version :9

Sequence 1:	NP_001036345.1	Gene:	Spn28Da / 34082	FlyBaseID:	FBgn0051902	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_033270.3	Gene:	Serpina1b / 20701	MGIID:	891970	Length:	413	Species:	Mus musculus

Alignment Length:	374	Identity:	106/374 - (28%)
Similarity:	182/374 - (48%)	Gaps:	20/374 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LGQFTKQLYRSFLQDNKQYNIIASPLCVEIGMSMILMGADGNTANELRTAL--NLPE-DKKNVAT 75
            ||.|...|||..:..:...||..||:.:....:|:.:|:.|:|..::...|  ||.: .:.::..
Mouse    48 LGDFAISLYRELVHQSNTSNIFFSPVSIATAFAMLSLGSKGDTHTQILEGLQFNLTQTSEADIHK 112

  Fly    76 IYDKLLTKLERGKKVAILHLANRLFVNETIGVNKRYNKLVNKHFRAEAEAIKLADRLKAAWAIND 140
            .:..||..|.|......|...|.||||..:.:.:::.:....|::||..::..|:..:|...|||
Mouse   113 SFQHLLQTLNRPDSELQLSTGNGLFVNNDLKLVEKFLEEAKNHYQAEVFSVNFAESEEAKKVIND 177

  Fly   141 WVLDQTLDNVKDIIIPSDLTPDESAVMINAAFFKGYWKTRFDKMNTKPKVFYVSKSYQVNVNMMS 205
            :|...|...:.:.:  .:|..|....:.|...|||.||..||..||:...|:|.||..|.|.||.
Mouse   178 FVEKGTQGKIVEAV--KELDQDTVFALANYILFKGKWKKPFDPENTEEAEFHVDKSTTVKVPMMM 240

  Fly   206 QVGRFKMRTSTI--DQIIELPFAYSNLSMVIVLPKDNGSLTQAEATI--ESYPQIVLTEMD--VH 264
            ..|...:...:|  ..::.:.:| .|.|.|.:||:| |.:...|.|:  |...:|:|....  |.
Mouse   241 LSGMLDVHHCSILSSWVLLMDYA-GNASAVFLLPED-GKMQHLEQTLNKELISKILLNRRRRLVQ 303

  Fly   265 VQLPKFKIDFRMELVETLKSMGIQDLFNSSSDISVLLNQSG-TRISQVVHKAFIEIDEEGGSAGS 328
            :.:|:..|.....|...:..:||..:||:.:|:|.:..::. .::|:.||||.:.|||.|..|
Mouse   304 IHIPRLSISGDYNLKTLMSPLGITRIFNNGADLSGITEENAPLKLSKAVHKAVLTIDETGTEA-- 366

  Fly   329 ASASPIRGLSDYATSVVTFTVNSPFVFMIRDD--DNIYFRGRVVDPLKK 375
            |:|:....:......::.|  :.||:|:|.::  .:..|.|:||||..|
Mouse   367 AAATVFEAVPMSMPPILRF--DHPFLFIIFEEHTQSPIFVGKVVDPTHK 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Da	NP_001036345.1	SERPIN	16..369	CDD:238101	99/364 (27%)
Serpina1b	NP_033270.3	SERPIN	53..410	CDD:214513	100/364 (27%)
Serpina1b	NP_033270.3	RCL	368..387		2/20 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010