Protein Alignment Spn28Da and SERPINB1

DIOPT Version :9

• Sequence 1: NP_001036345.1
• Gene: Spn28Da / 34082
• FlyBaseID: FBgn0051902
• Length: 384
• Species: Drosophila melanogaster
• Sequence 2: NP_109591.1
• Gene: SERPINB1 / 1992
• HGNCID: 3311
• Length: 379
• Species: Homo sapiens
• Alignment Length: 392
• Identity: 120/392 - (30%)
• Similarity: 189/392 - (48%)
• Gaps: 57/392 - (14%)

  Fly    16 QFTKQLYRSFLQDNKQYNIIASPLCVEIGMSMILMGADGNTANELRTALNLPEDKKNVATIYDKL 80
            :|...|:.:..::|...||..||..:...|:|:.:|..||||.:|....:. ...:.|.:.:..|
Human    10 RFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKTFHF-NTVEEVHSRFQSL 73

  Fly    81 LTKLERGKKVAILHLANRLFVNET--------IGVNKRYN-KLVNKHFRAEAEAIKLADRLKAAW 136
            ...:.:.....||.|||||:..:|        :...|.|. .|.:..|:..:|        .|..
Human    74 NADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVDFQHASE--------DARK 130

  Fly   137 AINDWVLDQTLDNVKDIIIPSDLTPDESAVMINAAFFKGYWKTRFDKMNTKPKVFYVSKSYQVNV 201
            .||.||..||...:.:::....:......|::||.:|||.||.:|.|..|....|.::|..:..|
Human   131 TINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRLNKKDRKTV 195

  Fly   202 NMMSQVGRF--------KMRTSTIDQIIELPFAYSNLSMVIVLPKD----NGSLTQAE--ATIES 252
            .||.|..:|        |.|      ::|||:....|||||:||.|    :..|.:.|  .|:|.
Human   196 KMMYQKKKFAYGYIEDLKCR------VLELPYQGEELSMVILLPDDIEDESTGLKKIEEQLTLEK 254

  Fly   253 YPQIVLTE----MDVHVQLPKFKIDFRMELVETLKSMGIQDLFNSS-SDISVLLNQSGTR---IS 309
            ..:....|    ::|:|.||:||::....|...|..:|:||||||| :|:|   ..||.|   ||
Human   255 LHEWTKPENLDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFNSSKADLS---GMSGARDIFIS 316

  Fly   310 QVVHKAFIEIDEEGGSAGSASASPIRGLSDYATSV--VTFTVNSPFVFMIRDDD--NIYFRGRVV 370
            ::|||:|:|::|||..|.:|:|    |::.:...:  ..||.:.||:|.||.:.  :|.|.||..
Human   317 KIVHKSFVEVNEEGTEAAAATA----GIATFCMLMPEENFTADHPFLFFIRHNSSGSILFLGRFS 377

  Fly   371 DP 372
            .|
Human   378 SP 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Da	NP_001036345.1	SERPIN	16..369	CDD:238101	118/387 (30%)
SERPINB1	NP_109591.1	SERPIN	4..379	CDD:294093	119/390 (31%)
		CARD-binding motif (CBM). /evidence=ECO:0000269|PubMed:30692621	351..379		11/27 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.930