DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Da and Serpinb2

DIOPT Version :9

Sequence 1:	NP_001036345.1	Gene:	Spn28Da / 34082	FlyBaseID:	FBgn0051902	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_001167641.1	Gene:	Serpinb2 / 18788	MGIID:	97609	Length:	415	Species:	Mus musculus

Alignment Length:	416	Identity:	111/416 - (26%)
Similarity:	187/416 - (44%)	Gaps:	71/416 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FTKQLYRSFLQDNKQYNIIASPLCVEIGMSMILMGADGNTANELRTALNL------------PED 69
            |...|.:...:.|...||..||..:...::::|:||.|||..::...|..            ||:
Mouse    11 FALNLLKQIEKSNSTQNIFISPWSISSTLAIVLLGAGGNTEQQMAKVLQFNEIGSYGITTRNPEN 75

  Fly    70 -----------KKNVATIYDKLLTKLERGKKV-----------------AILHLANRLFVNETIG 106
                       |:|    |...:.:.:.|.|:                 .:|..||:||..::..
Mouse    76 FSGCDFAQQIQKEN----YPSAILQAQAGDKIHSAFSSLSSTINTPQGDYLLESANKLFGEKSAR 136

  Fly   107 VNKRYNKLVNKHFRAEAEAIKLAD-RLKAAWAINDWVLDQTLDNVKDIIIPSDLTPDESAVMINA 170
            ..:.|.:|..|::..|.||:...: ..:|...||.||..||...:.:::....:..|...|::||
Mouse   137 FKEEYIQLSKKYYSTEPEAVDFLECAEEAREKINSWVKTQTKGEIPNLLPEGSVDEDTKMVLVNA 201

  Fly   171 AFFKGYWKTRFDKMNTKPKVFYVSKSYQVNVNMM-----SQVGRFK-MRTSTIDQIIELPFAYSN 229
            .:|||.|||.|:|.......|.|:....:.|.||     ..:|..| ::|    ||:|||.. .|
Mouse   202 VYFKGKWKTPFEKKLNGLYPFRVNSHESIPVQMMFLHAKLNIGYIKDLKT----QILELPHT-GN 261

  Fly   230 LSMVIVLPKD-----NG-SLTQAEATIESYPQIV----LTEMDVHVQLPKFKIDFRMELVETLKS 284
            :||:::||.:     .| .|.::|....::.:.:    |.|.||.|.:||||:....||...|:|
Mouse   262 ISMLLLLPDEIEDASTGLELLESEINFANFNKWISKDTLDEDDVVVYIPKFKLAQSYELKSILQS 326

  Fly   285 MGIQDLFN-SSSDISVLLNQSGTRISQVVHKAFIEIDEEGGSAGSASASPIRGLSDYATSVVTFT 348
            ||::|.|| ..::.|.:..::...:|:|.|:|.:::.|||..|...:.:.:.|.:.:...  .|.
Mouse   327 MGMEDAFNKGKANFSGMSERNDLFLSEVFHQASVDVTEEGTVAAGGTGAVMTGRTGHGGP--QFV 389

  Fly   349 VNSPFVFMIRD--DDNIYFRGRVVDP 372
            .:.||:|.|.|  ...|.|.||...|
Mouse   390 ADHPFLFFIMDKITHTILFVGRFSSP 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Da	NP_001036345.1	SERPIN	16..369	CDD:238101	109/411 (27%)
Serpinb2	NP_001167641.1	SERPIN	4..415	CDD:294093	110/414 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	216	1.000	Domainoid score	I2692
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	217	1.000	Inparanoid score	I3582
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.980