DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Da and Serpinh1

DIOPT Version :9

Sequence 1:	NP_001036345.1	Gene:	Spn28Da / 34082	FlyBaseID:	FBgn0051902	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_001104513.1	Gene:	Serpinh1 / 12406	MGIID:	88283	Length:	417	Species:	Mus musculus

Alignment Length:	364	Identity:	90/364 - (24%)
Similarity:	172/364 - (47%)	Gaps:	20/364 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LYRSFLQDNKQYNIIASPLCVEIGMSMILMGADGNTANELRTALNLPEDK-KNVATIYDKLLTKL 84
            ||::..:|....||:.|||.|...:.::.:|....||::.:..|:..:.: :.|.|...:||..|
Mouse    53 LYQAMAKDQAVENILLSPLVVASSLGLVSLGGKATTASQAKAVLSAEKLRDEEVHTGLGELLRSL 117

  Fly    85 ERG-KKVAILHLANRLFVNETIGVNKRYNKLVNKHFRAEAEAIKLADRLKAAWAINDWVLDQTLD 148
            ... .:.....|.:||:...::.....:.:...:|:..|...|...|:..|..:||:|. .||.|
Mouse   118 SNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWA-SQTTD 181

  Fly   149 NVKDIIIPSDLTPDESAVMINAAFFKGYWKTRFDKMNTKPKVFYVSKSYQVNVNMMSQVGRFKMR 213
            . |...:..|:...:.|:::||.|||.:|..:|.......:.|.|::||.|.|.||.:.|.:...
Mouse   182 G-KLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVTMMHRTGLYNYY 245

  Fly   214 TSTID--QIIELPFAYSNLSMVIVLPKDNGSLTQAEATIESYPQI-----VLTEMDVHVQLPKFK 271
            ....:  |::|:|.|:...|::|::|.....|.:.|..: :..|:     .:.:..|.:.|||..
Mouse   246 DDEKEKLQMVEMPLAHKLSSLIILMPHHVEPLERLEKLL-TKEQLKAWMGKMQKKAVAISLPKGV 309

  Fly   272 IDFRMELVETLKSMGIQDLFN-SSSDISVLLNQSGTRISQVVHKAFIEIDEEGGSAGSASASPIR 335
            ::...:|.:.|..:|:.:..: :.:|:|.:..:....::.|.|....|.|.|    |:.....|.
Mouse   310 VEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFEWDTE----GNPFDQDIY 370

  Fly   336 GLSDYATSVVTFTVNSPFVFMIRDDD--NIYFRGRVVDP 372
            |..: ..|...|..:.||:|::||:.  ::.|.||:|.|
Mouse   371 GREE-LRSPKLFYADHPFIFLVRDNQSGSLLFIGRLVRP 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Da	NP_001036345.1	SERPIN	16..369	CDD:238101	87/359 (24%)
Serpinh1	NP_001104513.1	serpinH1_CBP1	35..416	CDD:381003	90/364 (25%)
Serpinh1	NP_001104513.1	Prevents secretion from ER. /evidence=ECO:0000305	414..417
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010