DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn28Da and Serping1

DIOPT Version :9

Sequence 1:	NP_001036345.1	Gene:	Spn28Da / 34082	FlyBaseID:	FBgn0051902	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_033906.2	Gene:	Serping1 / 12258	MGIID:	894696	Length:	504	Species:	Mus musculus

Alignment Length:	385	Identity:	85/385 - (22%)
Similarity:	170/385 - (44%)	Gaps:	53/385 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TSVLGQFTKQLYRSFLQDN-KQYNIIASPLCVEIGMSMILMGADGNTANELRTALNLPEDKKNVA 74
            :..|..|:.:||.:|.... .:.|:..||..:...::.:|:||..:|.:.|.:.|:.|:|   .|
Mouse   148 SEALTDFSVKLYHAFSATKMAKTNMAFSPFSIASLLTQVLLGAGDSTKSNLESILSYPKD---FA 209

  Fly    75 TIYDKLLTKLERGKKVAILHLANRLFVNETIGVNKRYNKLVN--KHFRAEAEAIKLADRLKAAWA 137
            .::..|.....:|     :...:::|.:..:.:...|   ||  :.....:..:...|.......
Mouse   210 CVHQALKGFSSKG-----VTSVSQIFHSPDLAIRDTY---VNASQSLYGSSPRVLGPDSAANLEL 266

  Fly   138 INDWVLDQTLDNVKDIIIPSDLTPDESAVMINAAFFKGYWKTRFDKMNTKPKVFYVSKSYQVNVN 202
            ||.||.:.|...::.::  ..|..|...|::||.:....||..|:........||  |:..:.|.
Mouse   267 INTWVAENTNHKIRKLL--DSLPSDTCLVLLNAVYLSAKWKITFEPKKMMAPFFY--KNSMIKVP 327

  Fly   203 MMSQVGRFKMRTSTID------QIIELPFAYSNLSMVIVLPK-DNGSLTQAEATIESYPQI---V 257
            |||.|   |...:..|      ::.:|..:: |||.|||:|. ....|...|..:.  |.:   :
Mouse   328 MMSSV---KYPVAQFDDHTLKAKVGQLQLSH-NLSFVIVVPVFPKHQLKDVEKALN--PTVFKAI 386

  Fly   258 LTEMDV------HVQLPKFKIDFRMELVETLKSMGIQDLFNSSSDISV--LLNQSGTRISQVVHK 314
            :.::::      ::.:|..|:....:::..::.:   :.|:.:.|:::  |......::|.:.|:
Mouse   387 MKKLELSKFLPTYLTMPHIKVKSSQDMLSVMEKL---EFFDFTYDLNLCGLTEDPDLQVSAMKHE 448

  Fly   315 AFIEIDEEGGSAGSASASPIRGLSDYATSVVTFTVNSPFVFMIRDDDNIY--FRGRVVDP 372
            ..:|:.|.|..|.:|||      ..:..|:..|.|..||:|::.|..:.:  |.|||.||
Mouse   449 TVLELTESGVEAAAASA------ISFGRSLPIFEVQRPFLFLLWDQQHRFPVFMGRVYDP 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Da	NP_001036345.1	SERPIN	16..369	CDD:238101	80/375 (21%)
Serping1	NP_033906.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..67
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..141
		serpinG1_C1-INH	141..500	CDD:381006	82/381 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100