DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14535 and Kif3c

DIOPT Version :9

Sequence 1:	NP_001285726.1	Gene:	CG14535 / 34073	FlyBaseID:	FBgn0031955	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_445938.1	Gene:	Kif3c / 85248	RGDID:	621538	Length:	796	Species:	Rattus norvegicus

Alignment Length:	906	Identity:	200/906 - (22%)
Similarity:	314/906 - (34%)	Gaps:	288/906 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 KVKVMLRVADRDRNSGGTEPDFMALDKKKRQVTLTDPRTACPPPQAAQERAPMVAAPKMFAFDNL 108
            ||....|...|...:.|.| ..:.:|.|..||||.:||.|  |.:          .||.|.||.:
  Rat    12 KVVARCRPLSRKEEAAGHE-QILTMDVKLGQVTLRNPRAA--PGE----------LPKTFTFDAV 63

  Fly   109 FTGEDKQSDVCASALSEVIPAVLEGSDGCLLAMGYPATGQAQTVLGELGGGSGSGSASGSGVACS 173
            :....||:|:....:..:|.:||:|.:|.:.|.|...||:..|:             .|:.|...
  Rat    64 YDASSKQADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTM-------------QGTWVEPE 115

  Fly   174 L-GAAPCAIAWLYKGIQERRQKSGARFSVRVSAVGVSATK-PDALSQDLLISHAAESDDSP--GI 234
            | |..|.|...::..|...:.:   ::.||.|.:.:...: .|.||::  .....|..::|  |:
  Rat   116 LRGVIPNAFEHIFTHISRSQNQ---QYLVRASYLEIYQEEIRDLLSKE--PGKRLELKENPETGV 175

  Fly   235 YLRD--DF-------------LG------GPTELRAPTAERAALFL-------------DSALAG 265
            |::|  .|             ||      |.|.:...::...|:|:             |....|
  Rat   176 YIKDLSSFVTKNVKEIEHVMNLGNQARAVGSTHMNEVSSRSHAIFVITVECSERGSDGQDHIRVG 240

  Fly   266 RLK---SSGSTASGSSGCAAPLESALIFTLHVYQYSLSRKGGVAGGRSRLHIIDLGGCANRNG-- 325
            :|.   .:||.....:|...|...|          :.|..||..||         ||.:....
  Rat   241 KLNLVDLAGSERQNKAGPNTPGGPA----------TQSTAGGGGGG---------GGTSGSGSSG 286

  Fly   326 ---------GLPLSGIGNILLAILSGQR--HPPHKDHPLTPLLKDCLAPITCHVAIVAHVRP-EQ 378
                     .|.||.:||: :|.|:|.|  |.|::|..||.||:|.|.. .....:||.:.| ..
  Rat   287 ERPKEASKINLSLSALGNV-IAALAGNRSTHIPYRDSKLTRLLQDSLGG-NAKTIMVATLGPASH 349

  Fly   379 SYQDALSTIQIASR-------------------------IHRLR------------------RRK 400
            ||.::|||::.|:|                         |.||:                  |||
  Rat   350 SYDESLSTLRFANRAKNIKNKPRVNEDPKDTLLREFQEEIARLKAQLEKKGMLGKRPRRKSSRRK 414

  Fly   401 HRVPMPLAVGLAQGLGGNGSSAGSGADPSSSEISADTVIYMGPNDDATDGEHPPVYLPSLTAGDN 465
            ..|..|               ||.   |..:.|.|    ::...:|..:..|.|.. |:|.|...
  Rat   415 KAVSAP---------------AGY---PEGAVIEA----WVAEEEDDNNNNHRPPQ-PTLEAALE 456

  Fly   466 RGVMSKALKGSGLEKPPSKSASNSPMMM----KKAMAAEKAKKLPGSHTGSLKRQAGAGACSSPM 526
            :. |...|:.........|:|......:    |:.:..||.|.|.     .|||:..|....:
  Rat   457 KN-MENYLQEQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLE-----DLKREQQATELLA-- 513

  Fly   527 IPHEQPQIQAMGSPIPIPRHMVSKGSMVPSPKGSPMRRAHPGAALEQLEAGMRKITEEQWIDGPR 591
                 .:.:||.|.:.|               |......|.....:.||...::|.|::
  Rat   514 -----AKYKAMESKLLI---------------GGRNIMDHTNEQQKMLELKRQEIAEQK------ 552

  Fly   592 VSRAKVAEARHLMREVNHVK--------QCETWVDGPKSQSCRSLTA------------------ 630
             .|.:..:...|:|:...::        |.|..|   |::..:.|.|
  Rat   553 -RREREMQQEMLLRDEETMELRGTYSSLQQEVEV---KTKKLKKLYAKLQAVKAEIQDQHEEYIR 613

  Fly   631 --CNLPAAGGSQTQGY--------GFMDAHKKTMI--RQWVENQTTQ-VFQSTVSA--SNS---- 676
              .:|..|...||:..        .|:...:|..|  |.:::.:..| .||..|.|  :||
  Rat   614 VRQDLEEAQNEQTRELKLKYLIIENFIPPEEKNKIMNRLFLDCEEEQWKFQPLVPAGVNNSQMKK 678

  Fly   677 -PT-ALHWK--LSQLKQKSLDLPDRPAFNPEPSLDLNQPCFESLPLLDPAPPDGDEDEDSGPSEV 737
             || |:.:|  :||..:.::.:...|.:..|..:.|.         ||.:||...|.|.|...|.
  Rat   679 RPTSAVGYKRPISQYARVAMAMGSHPRYRAENIMFLE---------LDVSPPAIFEMEFSHDQEQ 734

  Fly   738 PP------ALPLLDDPLGSRDISQDNLHRMLSRHVSR----EQLHEAELVASRASSSHHPS 788
            .|      .|..||..|.....|:....|...:...|    ..:|     ||.||:..||:
  Rat   735 DPRVLHMERLMRLDSFLERPSTSKVRKSRSWCQSPQRPPPPSTVH-----ASMASAPLHPA 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14535	NP_001285726.1	Motor_domain	44..394	CDD:277568	102/429 (24%)
Kif3c	NP_445938.1	KISc_KIF3	9..367	CDD:276822	102/406 (25%)
		Kinesin	16..367	CDD:278646	100/402 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	251..292		10/59 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..421		5/38 (13%)
		GBP_C	<463..571	CDD:303769	25/141 (18%)
		coiled coil	540..551	CDD:293879	3/10 (30%)
		coiled coil	560..571	CDD:293879	2/10 (20%)
		Globular. /evidence=ECO:0000255	633..793		43/172 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..796		10/42 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900