DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14535 and Kif27

DIOPT Version :9

Sequence 1:	NP_001285726.1	Gene:	CG14535 / 34073	FlyBaseID:	FBgn0031955	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_780423.2	Gene:	Kif27 / 75050	MGIID:	1922300	Length:	1394	Species:	Mus musculus

Alignment Length:	851	Identity:	165/851 - (19%)
Similarity:	289/851 - (33%)	Gaps:	270/851 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 MVAAPKMFAFDNLFTGEDKQSDVCASALSEVIPAVLEGSDGCLLAMGYPATGQAQTVLGELGGGS 160
            ::...::|.||.:|.....|.:|..:.:..::.:::||.:..:.|.|...:|:..|:    |||.
Mouse    38 IIGRDRVFTFDFVFGKNSTQDEVYNTCIKPLVLSLIEGYNATVFAYGQTGSGKTYTI----GGGH 98

  Fly   161 GSGSASGSGVACSLGAAPCAIAWLYKGIQERRQKSGARFSVRVSAVGVSATKPDALSQDLLISHA 225
            .:....|     ..|..|.||..:::.|.|   .....|.::||.:.|  .|.|.  :|||....
Mouse    99 VASVVEG-----QKGIIPRAIQEIFQSISE---NPSIDFKIKVSYIEV--YKEDL--RDLLELET 151

  Fly   226 AESDDSPGIYLRDDFLG-----GPTELRAPTAERAALFLDSALAGRLKSSGSTASGSSGCAAPLE 285
            :..|    :::|:|..|     |..|.:..:.|.....|....|.|  .:|:|.......    .
Mouse   152 SMKD----LHIREDEKGNTVIVGAKECQVESVEDVMSLLQVGNAAR--HTGTTQMNEHSS----R 206

  Fly   286 SALIFTLHVYQYSLSRKGGVAGG-------RSRLHIIDLGGCANR-----------------NGG 326
            |..|||:.|.|...:.:....|.       .|:.|.:||.| :.|                 |.|
Mouse   207 SHAIFTISVCQVEKNAEAAENGEWYSHRHIVSKFHFVDLAG-SERVTKTGNTGERFKESIQINSG 270

  Fly   327 LPLSGIGNILLAILSGQR---HPPHKDHPLTPLLKDCL------APITCHVAIVAHVRPEQS-YQ 381
              |..:||::.|:...:|   |.|::|..:|.||||.|      ..|||       |.|..| :.
Mouse   271 --LLALGNVISALGDPRRKSSHIPYRDAKITRLLKDSLGGSAKTVMITC-------VSPSSSDFD 326

  Fly   382 DALSTIQIASRIHRLRRRKHRVPMPLAVG----------LAQGLGGNGSSAGSGADPSSSEISAD 436
            ::|::::.|:|...:|.:......|.|..          |.:.|..:.:|....:..||..:...
Mouse   327 ESLNSLKYANRARNIRNKPALNISPQADRMDEMEFEIKLLREALQSHQASISQASQASSENVPDQ 391

  Fly   437 TVIY-------------MGPND----------DATDG-------EHPPVYLPSLTAGDNRGVMSK 471
            ..|:             :|..|          |..|.       :|......|.|....:.|::.
Mouse   392 NRIHSLEEQVAQLQEECLGYQDCIEQAFAFLVDLKDAVKLNQKQQHKLQEWFSRTQEVRKAVLTP 456

  Fly   472 ALKGSG---LEKPPSKSASNSPMMMKKAMAAEKAKKLPGSHTGSLKRQAGAGACSSPMIPHEQPQ 533
            .....|   ||:.|...   :.:.:|:                .||:...|.|....:...:..:
Mouse   457 LPGNQGIGNLEEGPQHL---TVLQLKR----------------ELKKYQCALAADQVVFTQKDLE 502

  Fly   534 IQAMGSPIPIPRHMVSKGSMVPSPKGSPMRRAHPGAALE------QLEAGMRK-------ITEEQ 585
            ::.:.:.:.: ....|||..|...:...:.|......:|      ||.|.:.|       ..:|.
Mouse   503 LEELRTQVQL-MMQESKGHAVSLKEAQKVNRLQNEKIIEQQLLVDQLSAELAKRSLSVPTSAKES 566

  Fly   586 WIDGPRVSRAKVAEARHLMREVNHVKQCET----WVDGPKSQS----CRSLTACNLPAA-GGSQT 641
            ..|||   .|:.:|.|      .|....|:    :|..|..|.    |.|....:|... .|.:|
Mouse   567 CGDGP---DARASEKR------PHTAPFESHWGHYVYIPSRQDFKKVCSSTPVYSLDQVFAGFRT 622

  Fly   642 QGYGFMDAHKKTMIRQWVENQTTQVFQSTVSASNSPTALHWKLSQLKQKSLDLPDRPAFNPEPSL 706
                     :..|:...:|:|              ...||.:.|
Mouse   623 ---------RSQMLMGHLEDQ--------------DEVLHCQFS--------------------- 643

  Fly   707 DLNQPCFESLPLLDPAPPDGDEDEDSGPSEVPP----------------ALPLLDDP-------- 747
                              |..:||||...|.|.                :|..|.|.
Mouse   644 ------------------DNSDDEDSEGQEKPRVRSRSHSWAKKPGSVCSLVELSDTQAESQRSY 690

  Fly   748 LGSRDISQDNLHRMLSRHVSREQLHEAELVASRASSSHHPSQRSIDCGLQVTEEEI--------- 803
            ||:.|:..::|..  |:.::.::|..:||:.::|..    ..|.:...:::.|:.|
Mouse   691 LGNGDLKMESLQE--SQEINLQKLRTSELILNKAKQ----KMRELTINIRMKEDLIKELIKTGNN 749

  Fly   804 ARTMSR 809
            |:::||
Mouse   750 AKSVSR 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14535	NP_001285726.1	Motor_domain	44..394	CDD:277568	81/336 (24%)
Kif27	NP_780423.2	KISc_KIF4	4..342	CDD:276823	81/339 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..582		7/31 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	642..665		8/61 (13%)
		Smc	721..>1096	CDD:224117	7/39 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	886..916
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1267..1319
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1325..1344
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910