DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14535 and kif15

DIOPT Version :9

Sequence 1:	NP_001285726.1	Gene:	CG14535 / 34073	FlyBaseID:	FBgn0031955	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_002666969.1	Gene:	kif15 / 573988	ZFINID:	ZDB-GENE-050622-16	Length:	1376	Species:	Danio rerio

Alignment Length:	1052	Identity:	194/1052 - (18%)
Similarity:	337/1052 - (32%)	Gaps:	393/1052 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VKVMLRVADRDRNSG-GTEPDFMALDKKKRQVTLTDPRTA---CPPPQAAQERAPMVAAPKMFAF 105
            :||.:||....:.:| .|:.|....      :|::.|:|.   |.|            .|:.|.:
Zfish    20 IKVFVRVRPLTQGTGLSTDGDHSLC------LTVSSPQTVRLHCKP------------EPRTFTY 66

  Fly   106 DNLFTGEDKQSDVCASALSEVIPAVLEGSDGCLLAMGYPATGQAQTVLG--ELGGGSGSGSASGS 168
            |::......|.:|.:|....::.:.:.|.:|.:.|.|...:|:..|:||  ||...|..
Zfish    67 DHVADMNTSQEEVFSSVAKNIVESCMNGYNGTIFAYGQTGSGKTFTMLGPSELDNFSDE------ 125

  Fly   169 GVACSLGAAPCAIAWLYKGIQERRQKSGA--RFSVRVSAVGVSATKPDALSQDLLISHAAESDDS 231
                ..|..|.:..:|:..|....::||.  .|..:.|.:.:.    :....|||.|      .|
Zfish   126 ----LRGVIPRSFEYLFFLINREVERSGGTKSFLCKCSFIEIY----NEQIYDLLDS------VS 176

  Fly   232 PGIYLRDD-----FLGGPTELRAPTAERAALFLDSALAGRLKSSGSTASGSSGCAAPLESALIFT 291
            ..::||:|     |:.|..|..|.:|..|...|......|..:|.|....||      .|..:||
Zfish   177 TSLFLREDIKRGVFVEGSVEKYAASAAEAYQVLSMGWRNRRVASTSMNRESS------RSHAVFT 235

  Fly   292 LHVYQYSLSRKGG--VAGGR-SRLHIIDLGG------------------CANRNGGLPLSGIGNI 335
            :.:.    |::.|  |...| |:|:::||.|                  ..||:    |..:|.:
Zfish   236 MTLE----SKETGQEVVNIRTSQLNLVDLAGSERQRDTHTEGSRLKEASSINRS----LMCLGQV 292

  Fly   336 LLAIL---SGQ-RHPPHKDHPLTPLLKDCLAPITCHVAIVAHVRP-EQSYQDALSTIQIASR--- 392
            ::|::   :|: ||..::|..||.||:|.|.. .....|:|:|.| .:.:.:.|||:|.|.|
Zfish   293 IMALMDVSNGKNRHICYRDSKLTFLLRDSLGG-NAKTYIIANVHPGSKCFGETLSTLQFAQRAKL 356

  Fly   393 --------------IHRLRRRKHRVPMPLAVGLAQGLGGNGSSAGSGADPSSSEISADTVIYMGP 443
                          :.:|:....::...||..|:||                      .::.:.|
Zfish   357 IKNKAMVNEDTQGNVRQLQAEVRKLKEQLANALSQG----------------------RIVELAP 399

  Fly   444 NDDATDGEHPPVYLPSLTAGDNRGVMSKALKGSGLEKP--PSKSASNSPMMMKKAMAAEKAK--- 503
            .|..:|...|.|           ...::.::.....|.  ..|.|....:...:|..|:|.|
Zfish   400 TDATSDQSEPEV-----------SYKTQFIQAMNFWKKIHEEKKALQQKVSQLEAAWAQKEKFIQ 453

  Fly   504 ------KLPGSHTGSLKRQAGAGACSSPMIPHEQPQIQAMGSPIPIPRHMVSKGSMVPSPKGSPM 562
                  |....|...||::...|                                         .
Zfish   454 SNRMILKFRDDHIAQLKKELQTG-----------------------------------------Q 477

  Fly   563 RRAHPGAALEQLEAGMRKITEEQWIDGPRVSRAKVAEARHLMREVNHVKQCETWVDGPKSQSCRS 627
            |...|....:||:..:| :..:|....||:.| ..||...|..|:..::..:: |........:|
Zfish   478 RSVEPEELNKQLQDEIR-LLRDQVEHNPRMMR-YAAENCSLREEIRALRALDS-VKSAMESKAQS 539

  Fly   628 LTACNLPAAGGSQTQGYGFMDAHKKTMIRQWVENQTTQVFQSTVSASNSPTALHWKLSQLKQKSL 692
            |||.                   :||.: |.:|.|.|
Zfish   540 LTAL-------------------EKTFL-QLLEAQKT---------------------------- 556

  Fly   693 DLPDRPAFNPEPSLDLNQPCFESLPLLDPAPPDGDEDEDSGPSEVPPALPLLDDPLGSRDISQDN 757
                                               ||.:..|       |....|:....:|..:
Zfish   557 -----------------------------------EDSNGAP-------PTYSTPVTMETLSSVS 579

  Fly   758 LHRMLSRHVSREQLHEAELVASRASSSHHPSQRSIDCGLQVTEEEIARTMSRDRDHDPSAHPLSA 822
            :.||..:.:.:    ::||.|:..:.....         :||::::|...|..|..:.|
Zfish   580 MERMKVQLLQK----QSELTATIQAFEEFK---------EVTKKQVAELESERRYFEKS------ 625

  Fly   823 LSHCDNISFVSSFNMACESFSECGE-RARQQFDQLARLHEIFTSQLAMAEVTPSAALFRTDIGSV 886
                         |...|...|..: .::|:..||.::|         ||..           .:
Zfish   626 -------------NKHLEKILEATKAHSKQEVSQLNKIH---------AETI-----------KI 657

  Fly   887 FSEPVYHFNVGQSSVCSEPAYRLTPSPPKQPSHSPSQGSLPSLNGIMEIAGMDDYALLRQPDGAS 951
            .:.|...:|:....|           |...|.|         |||..|...:||....:.|...:
Zfish   658 LTTPTKGYNLRNRLV-----------PLSSPEH---------LNGQAEEMDVDDIQNEQPPPEMN 702

  Fly   952 D----------PNLQKGEKRFTPQHDD-----------ICELDEKSMAAAVGKGN---------- 985
            :          ..:|:...|...|.|:           :.:|:|: :..|..|.|
Zfish   703 ELACEALTEELKQMQEQALRVQGQLDEEEAKNRKLLQQMSKLEEQ-VTIATEKSNRTEQMFGAER 766

  Fly   986 -SLEDAQHKLNE 996
             ||::.|.:|.|
Zfish   767 HSLQEEQERLQE 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14535	NP_001285726.1	Motor_domain	44..394	CDD:277568	94/404 (23%)
kif15	XP_002666969.1	KISc_KLP2_like	18..367	CDD:276824	94/399 (24%)
		KISc	19..364	CDD:214526	94/396 (24%)
		SbcC	371..1007	CDD:223496	100/648 (15%)
		Kinesin-relat_1	462..547	CDD:289481	23/147 (16%)
		Ax_dynein_light	<602..658	CDD:287215	15/103 (15%)
		GBP_C	<707..805	CDD:303769	14/73 (19%)
		Mplasa_alph_rch	709..1360	CDD:275316	14/71 (20%)
		coiled coil	776..788	CDD:293879	2/3 (67%)
		coiled coil	794..805	CDD:293879
		HMMR_C	1262..>1372	CDD:292530
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810