DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14535 and KIF15

DIOPT Version :9

Sequence 1:	NP_001285726.1	Gene:	CG14535 / 34073	FlyBaseID:	FBgn0031955	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_016862373.1	Gene:	KIF15 / 56992	HGNCID:	17273	Length:	1411	Species:	Homo sapiens

Alignment Length:	1158	Identity:	226/1158 - (19%)
Similarity:	406/1158 - (35%)	Gaps:	290/1158 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VKVMLRV---ADRDRNSGGTEPDFMALDKKKRQVTLTDPRTACPPPQAAQERAPMVAAPKMFAFD 106
            :||.:|:   |:|..::.|.:...:::      ::.|..|....|            .||.|.||
Human    27 IKVFVRIRPPAERSGSADGEQNLCLSV------LSSTSLRLHSNP------------EPKTFTFD 73

  Fly   107 NLFTGEDKQSDVCASALSEVIPAVLEGSDGCLLAMGYPATGQAQTVLGELGGGSGSGSASGSGVA 171
            ::...:..|..|.|:....::.:.:.|.:|.:.|.|...:|:..|::|.....:.|.:..
Human    74 HVADVDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLR----- 133

  Fly   172 CSLGAAPCAIAWLYKGIQERRQKSGA--RFSVRVSAVGVSATKPDALSQDLLISHAAESDDSPGI 234
               |..|.:..:|:..|...::|:||  .|..:.|.:.:.    :....|||.|.:|      |:
Human   134 ---GVIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIY----NEQIYDLLDSASA------GL 185

  Fly   235 YLRDD-----FLGGPTELRAPTAERAALFLDSALAGRLKSSGSTASGSSGCAAPLESALIFTLHV 294
            |||:.     |:.|..|....:|..|...|......|..:|.|....||      .|..:||:.:
Human   186 YLREHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESS------RSHAVFTITI 244

  Fly   295 YQYSLSRKGGVAGGR-SRLHIIDLGGCANRNG----GLPLSGIGNI-------------LLAILS 341
              .|:.:...:...| |.|:::||.|...:..    |:.|...|||             |:.:.:
Human   245 --ESMEKSNEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGN 307

  Fly   342 G-QRHPPHKDHPLTPLLKDCLAPITCHVAIVAHVRP-EQSYQDALSTIQIASR------------ 392
            | |||..::|..||.||:|.|.. ....||:|:|.| .:.:.:.|||:..|.|
Human   308 GKQRHVCYRDSKLTFLLRDSLGG-NAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNE 371

  Fly   393 -----IHRLRRRKHRVPMPLAVGLAQGLGGNGSSAGSGADPSSSEISAD--TVIYMGPNDDATDG 450
                 :.:|:....|:...||            ...||..|..|.::.|  ...||....:|
Human   372 DTQGNVSQLQAEVKRLKEQLA------------ELASGQTPPESFLTRDKKKTNYMEYFQEA--- 421

  Fly   451 EHPPVYLPSLTAGDNRGVMSKALKGSGLEKPPSKSASNSPMMMK----KAMAAEKAKKLPGSHTG 511
                :.....:..:.:.::.|..:...|.....|...::.|::|    :.:..||
Human   422 ----MLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEK---------- 472

  Fly   512 SLKRQAGAGACSSPMIPHEQP--------QIQAMGSPIP----IPRHMVSKGSMVPSPKG----S 560
             |.:::..|     .:|.||.        :||.:...|.    :.::.:...|:....:.    .
Human   473 -LHKESRGG-----FLPEEQDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLE 531

  Fly   561 PMRRAH--PGAALEQLE------AGMRKITEEQWIDGPRVSRAKV---------AEARHLMREVN 608
            |::||.  ....:.:||      :||.|..:.|....|:..:...         |:...:..|:|
Human   532 PVKRAQEMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELN 596

  Fly   609 HVKQ-CETWVDGPKSQ------SCRSLTACNLPAAGGSQTQGYGFMDAHKKTMIRQWVENQTTQV 666
            :.|| .|.:.:..:.:      ..:||...||...        ..::| .|...||.| :|..::
Human   597 NSKQEYEEFKELTRKRQLELESELQSLQKANLNLE--------NLLEA-TKACKRQEV-SQLNKI 651

  Fly   667 FQSTVSASNSPTALHWKLSQL----------------KQKSLDLPDRPAFNPEPSLDLNQPCFES 715
            ...|:...|    :.|..:.|                ..|:..|..||.    |.|......|.|
Human   652 HAETLKLKN----VMWIYNDLFNLENAGFFPIQIITTPTKAYQLHSRPV----PKLSPEMGSFGS 708

  Fly   716 L-----PLLD------PAPPDGDEDEDSGPSEVPPALPLLDDPLGSRDISQDNLHRMLSRHVSRE 769
            |     .:||      |.||:.:|......||....:......|.::...:::.:..|.:||.:.
Human   709 LYTQNSSILDNDILNEPVPPEMNEQAFEAISEELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKL 773

  Fly   770 QLHEAEL--VASRASSSHHPSQRSIDCGLQVTEEEIARTMSRDRDHDPSAHPLSALSHCDNISFV 832
            :.|..::  :.|.........|..:...|.|.|:::..|.:::.......|.|..:.|..: ..:
Human   774 EHHSTQMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSAD-KEL 837

  Fly   833 SSFNMACESFSECGERARQQFDQLARLHEIFTSQLAMAEVTPSAALFRTDIGSVFSEPVYHFNVG 897
            ||..:...||....|:   :|::|:..|.....||....:.....|
Human   838 SSVKLEYSSFKTNQEK---EFNKLSERHMHVQLQLDNLRLENEKLL------------------- 880

  Fly   898 QSSVCSEPAYRLTPSPPKQPSHSPSQGSLPSLNGIMEIAGMDDYALLRQPDGASDPNLQKGEKRF 962
            :|..|.:.:|                      :.:.||...:...|.|        |||..:|..
Human   881 ESKACLQDSY----------------------DNLQEIMKFEIDQLSR--------NLQNFKKEN 915

  Fly   963 TPQHDDICELDEKSMAAAVGKGNSL-----EDAQHKLNEITNILPLAAQSRLPLLPLNTSSEAYD 1022
            .....|:..|.| .:.|...:.|.|     ||.::...||..:|....|.:           ..:
Human   916 ETLKSDLNNLME-LLEAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEK-----------QKE 968

  Fly  1023 SGHDSNSTPRTSKHSGISRRAESGYHSVATVRDSDESSFASGMSKGQRHRITV 1075
            :........:..|........|....|:...||||:...|..|::.|..|.:|
Human   969 TAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRTSV 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14535	NP_001285726.1	Motor_domain	44..394	CDD:277568	91/395 (23%)
KIF15	XP_016862373.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900