DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14535 and kif9

DIOPT Version :9

Sequence 1:	NP_001285726.1	Gene:	CG14535 / 34073	FlyBaseID:	FBgn0031955	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_001922460.1	Gene:	kif9 / 553438	ZFINID:	ZDB-GENE-160728-129	Length:	764	Species:	Danio rerio

Alignment Length:	805	Identity:	156/805 - (19%)
Similarity:	272/805 - (33%)	Gaps:	233/805 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 QSDVCASALSEVIPAVLEGSDGCLLAMGYPATGQAQTVLGELGGGSGSGSASGSGVACSLGAAPC 179
            |.|:.......|:....:|.:|.::..|....|:..|:.|            .:......|..|.
Zfish    65 QEDLYDRVARSVVLGAFKGYNGTIMCFGQTGAGKTYTMTG------------AAETYKQRGIIPR 117

  Fly   180 AIAWLYKGIQERRQKSGARFSVRVSAVGV-SATKPDALSQDLLISHAAESDDSP--GIYLRDDFL 241
            ||..::   ||..|::...|||.:|.:.: :.|..|.||       :.:...:|  |::...:..
Zfish   118 AIQEVF---QEVEQRADYTFSVHLSFLEIYNETMVDLLS-------SLKQGKAPGSGLFTVVEEP 172

  Fly   242 GGPTELRAPTA------ERAALFLDSALAGRLKSSGSTASGSSGCAAPLESALIFTLHVYQYS-- 298
            ||...::..:.      |.|...|......|:....:....||      .|..|||:|:...|
Zfish   173 GGGVSVKGLSVHLVHNEEEALNLLFEGEMNRIIGEHALNKHSS------RSHCIFTIHIESRSRT 231

  Fly   299 LSRKGGVAGGRSRLHIIDLGGC--ANRNG------------GLPLSGIGNILLAILSGQR-HPPH 348
            ||....:.   |:|:::||.|.  .::.|            ...||.:..::||:...:| |.|.
Zfish   232 LSEAKYIT---SKLNLVDLAGSERLSKTGSEGQVQMEAMYINKSLSFLEQVILALADSRREHVPF 293

  Fly   349 KDHPLTPLLKDCLAPITCHVAIVAHVRPEQS-YQDALSTIQIASRIHRLRRR----KHRVPMPLA 408
            :...||..|||.|.. .|:..:||::..:.| .::.|||::.|:|:..::.:    :|..|:...
Zfish   294 RQSKLTHALKDSLGG-NCNTVLVANIYGDASQIEETLSTLRFATRMKCVQTKPSINEHIDPVIQV 357

  Fly   409 VGL---AQGLGGNGSSAGSGADPSSSEISADTVI---------YMGPNDDA-------------- 447
            ..|   .|.|....||.....:..::||.::|.:         |:..:.|.
Zfish   358 KRLEKEIQFLKEELSSYNPLTNRLTNEILSETQVEEVRTQVQRYLSGSLDEIPIVSSTQIQEVFS 422

  Fly   448 ---------------------TDGEHPPVYLPSLTAGDNRGVMSKALK---GSGLEK-------- 480
                                 |..|......||..:..:.|.:.:...   |.||.|
Zfish   423 QFKKVMLEQQKKLQEQLCQRNTRVEKAMNTTPSTVSEKSEGAVGEVESYGYGLGLAKSSQRHQQA 487

  Fly   481 --PPSKSASNSPMMMKKAMAAEKAKKLPGSHTGSLKRQAGAGACSSPMIPHEQPQIQAMGSPIPI 543
              |.|..|.|...:.:|.:|||.:...|.:.:            .|.:..|:         |.|:
Zfish   488 VSPKSSKARNDKQINRKEVAAENSNVQPLTMS------------ESDLTTHK---------PQPL 531

  Fly   544 PRHMVSKGSMVPSPKGSPMR--RAHPGAALEQLEAGMRKITEEQWIDGPRVS--RAKVAEARHLM 604
            .....:..|  |.||.....  :|..|:.:.::      :.|.:.:...|.|  ||.........
Zfish   532 EEQQPTTDS--PPPKAEAFEDFKAEQGSEINRI------LKENKAVLSERTSQLRALTNVINVTK 588

  Fly   605 REVNHVKQCETWVDGPKSQSCRSLTACNLPAAGGSQTQGYG-FMDAHKKTMIR----------QW 658
            ||::|:           :...|...         .|.||.| ||.|..:.::.          :.
Zfish   589 REIDHI-----------TSDLRQFR---------EQRQGQGEFMSADGEPVLEVEELSLVMKLKE 633

  Fly   659 VENQTTQVFQSTVSASNSPTALHWKLSQLKQKSLD-----------LPDRPAFNPEPSLDLNQPC 712
            ::|:..|.::...:...........::|.:.:.|.           ||.
Zfish   634 LKNRYRQTYEELRTTETEIRYCAHLVNQCRMRLLTEFENWYNESFLLPG---------------- 682

  Fly   713 FESLPLLDPAPPDGDEDEDSGPSEVP--PALPLL--DDPL-----GSRDISQDNLH-RMLSRHVS 767
             |.|.:|:..|        ..|..:|  .||.|:  |||.     .|..:|..|.: |.|.|..|
Zfish   683 -EVLSVLENGP--------VRPGHIPVDKALTLMEDDDPQEPHADTSSAVSYYNAYNRTLQRRGS 738

  Fly   768 REQLHEAELVASRASSSHHPSQRSI 792
            |:.....:.|....|....|...|:
Zfish   739 RQVSQSPDSVRGSRSKMKLPPILSV 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14535	NP_001285726.1	Motor_domain	44..394	CDD:277568	70/305 (23%)
kif9	XP_001922460.1	Motor_domain	7..339	CDD:277568	70/305 (23%)
kif9	XP_001922460.1	Kinesin	13..339	CDD:278646	70/305 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900