DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14535 and KIF6

DIOPT Version :9

Sequence 1:	NP_001285726.1	Gene:	CG14535 / 34073	FlyBaseID:	FBgn0031955	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_005248961.1	Gene:	KIF6 / 221458	HGNCID:	21202	Length:	842	Species:	Homo sapiens

Alignment Length:	875	Identity:	170/875 - (19%)
Similarity:	301/875 - (34%)	Gaps:	201/875 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 FAFDNLFTGEDKQSDVCASALSEVIPAVLEGSDGCLLAMGYPATGQAQTVLGELGGGSGSGSASG 167
            |.|..:|..:..|..|..:....|..:||.|.:|.:.|.|...:|:..|:.|      |:...|.
Human    58 FKFQRIFDQDANQETVFENIAKPVAGSVLAGYNGTIFAYGQTGSGKTFTITG------GAERYSD 116

  Fly   168 SGVACSLGAAPCAIAWLYKGIQERRQKSGARFSVRVSAVGVSATKPDALSQDLL-ISHAAES-DD 230
            .|:      .|..::::::.:|:...|.   ::..:|.:.:.    :....||| ..|.|.| :|
Human   117 RGI------IPRTLSYIFEQLQKDSSKI---YTTHISYLEIY----NECGYDLLDPRHEASSLED 168

  Fly   231 SPGIYLRDD-----FLGGPTELRAPTAERA--ALFLDSALAGRLKSSGSTASGSSGCAAPLESAL 288
            .|.:.:.:|     .|...|..:|.|.|.|  .|||........::..:.||..|.|
Human   169 LPKVTILEDPDQNIHLKNLTLHQATTEEEALNLLFLGDTNRMIAETPMNQASTRSHC-------- 225

  Fly   289 IFTLHVYQYSLSRKGGVAGGRSRLHIIDLGGCAN--RNG------------GLPLSGIGNILLAI 339
            |||:|:   |....|......::||::||.|...  :.|            .|.|..:..:::|:
Human   226 IFTIHL---SSKEPGSATVRHAKLHLVDLAGSERVAKTGVGGHLLTEAKYINLSLHYLEQVIIAL 287

  Fly   340 LSGQR-HPPHKDHPLTPLLKDCLAPITCHVAIVAHVRPE-QSYQDALSTIQIASRIHRLR----- 397
            ....| |.|:::..:|.:|:|.|.. .|...::|.:..| ::..:::||.:.|.|:..::
Human   288 SEKHRSHIPYRNSMMTSVLRDSLGG-NCMTTMIATLSLEKRNLDESISTCRFAQRVALIKNEAVL 351

  Fly   398 ----------RRKHRVPMPLAVGLAQGLGGNGSSAGSGADPSSSE---------ISADTVIYMGP 443
                      :|..:....|...||...|...:.|.:.|:....|         ..:|:.:.:|.
Human   352 NEEINPRLVIKRLQKEIQELKDELAMVTGEQRTEALTEAELLQLEKLITSFLEDQDSDSRLEVGA 416

  Fly   444 NDDATDGEHPPVYLPSLTAG----DNRGVMSKALKGSGLEKPPS-----------KSASNSPMMM 493
              |.....|...:|..|...    :|..|.|:: |....::|..           |...|...::
Human   417 --DMRKVHHCFHHLKKLLNDKKILENNTVSSES-KDQDCQEPLKEEEYRKLRDILKQRDNEINIL 478

  Fly   494 KKAMAAEKAKKLPGSHTGSLKRQAGAGACSSPM---IPHEQPQIQAMGSPIPIPRHMV--SKGSM 553
            ...:..||.|.....|...:.|:....:.|.|.   .|.|..:::...:|.......:  .:.|:
Human   479 VNMLKKEKKKAQEALHLAGMDRREFRQSQSPPFRLGNPEEGQRMRLSSAPSQAQDFSILGKRSSL 543

  Fly   554 VPSPKGSPMRRAHPGAALEQLEAGMRKITEEQWIDG------PRVSRAK-----VAEAR----HL 603
            :....|  ||........|..|...|...:...||.      .|.|.||     :.|||    ||
Human   544 LHKKIG--MREEMSLGCQEAFEIFKRDHADSVTIDDNKQILKQRFSEAKALGESINEARSKIGHL 606

  Fly   604 MREV--NHVKQCETWVDGPKSQSCRSLTACNLPAAGGSQTQGYGFMDAHKKTMIRQWVENQTTQV 666
            ..|:  .|::|.                     |.|.|:......|...::..:|..:|.:..:
Human   607 KEEITQRHIQQV---------------------ALGISENMAVPLMPDQQEEKLRSQLEEEKRR- 649

  Fly   667 FQSTVSASNSPTALHWKLSQLKQKSLDLPDRPAF-----NPEPSLDLNQPCFESLPLLDPAPPDG 726
             ..|:........:..:..||......:..:..|     ....:|.:|.|...||....|.....
Human   650 -YKTMFTRLKALKVEIEHLQLLMDKAKVKLQKEFEVWWAEEATNLQVNSPAVNSLDHTKPFLQTS 713

  Fly   727 D---------EDEDSGPSEVPPALPLLDDPLGSRDISQDNLHRMLSRHVSREQLHEAELVASRAS 782
            |         .::.||..||.      |...|..|:...|..::|               .|...
Human   714 DSQHEWSQLLSNKSSGGWEVQ------DQGTGRFDVCDVNARKIL---------------PSPCP 757

  Fly   783 SSHHPSQRSIDCGLQVTEEEIARTMSRDRDHDPSAHPLSALSHCDN--ISFVSS---------FN 836
            |.|...|.|....|   |:.|.:       ...|:.||:..|..|:  |:|:.:         ..
Human   758 SPHSQKQSSTSTPL---EDSIPK-------RPVSSIPLTGDSQTDSDIIAFIKARQSILQKQYLQ 812

  Fly   837 MACESFSECGERARQQFDQLARLHEIFTSQ 866
            :.|..|.:....:.|.......|.::..::
Human   813 LLCSLFPKSAVSSAQASTNRKGLSDVLVTR 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14535	NP_001285726.1	Motor_domain	44..394	CDD:277568	73/315 (23%)
KIF6	XP_005248961.1	Motor_domain	5..343	CDD:277568	73/315 (23%)
KIF6	XP_005248961.1	Kinesin	11..345	CDD:278646	73/317 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900