DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14535 and Kif3c

DIOPT Version :9

Sequence 1:	NP_001285726.1	Gene:	CG14535 / 34073	FlyBaseID:	FBgn0031955	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_032471.2	Gene:	Kif3c / 16570	MGIID:	107979	Length:	796	Species:	Mus musculus

Alignment Length:	936	Identity:	199/936 - (21%)
Similarity:	320/936 - (34%)	Gaps:	277/936 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 KVKVMLRVADRDRNSGGTEPDFMALDKKKRQVTLTDPRTACPPPQAAQERAPMVAAPKMFAFDNL 108
            ||....|...|...:.|.| ..:.:|.|..||||.:||.|  |.:          .||.|.||.:
Mouse    12 KVVARCRPLSRKEEAAGHE-QILTMDVKLGQVTLRNPRAA--PGE----------LPKTFTFDAV 63

  Fly   109 FTGEDKQSDVCASALSEVIPAVLEGSDGCLLAMGYPATGQAQTVLGELGGGSGSGSASGSGVACS 173
            :....||:|:....:..:|.:||:|.:|.:.|.|...||:..|:             .|:.|...
Mouse    64 YDASSKQADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTM-------------QGTWVEPE 115

  Fly   174 L-GAAPCAIAWLYKGIQERRQKSGARFSVRVSAVGVSATK-PDALSQDLLISHAAESDDSP--GI 234
            | |..|.|...::..|...:.:   ::.||.|.:.:...: .|.||::  .....|..::|  |:
Mouse   116 LRGVIPNAFEHIFTHISRSQNQ---QYLVRASYLEIYQEEIRDLLSKE--PGKRLELKENPETGV 175

  Fly   235 YLRDDFLGGPTELRAPTAERAALFLDSALAGRLKSSGSTASGSSGCAAPLESALIFTLHVYQYSL 299
            |::|  |...........|..     ..|..:.::.|||....    ....|..||.:.|   ..
Mouse   176 YIKD--LSSFVTKNVKEIEHV-----MNLGNQARAVGSTHMNE----VSSRSHAIFVITV---EC 226

  Fly   300 SRKGGVAGGR-----SRLHIIDLGGCANRN-----------------GG---------------- 326
            |.:|  :.|:     .:|:::||.|...:|                 ||
Mouse   227 SERG--SDGQDHIRVGKLNLVDLAGSERQNKAGPNAAGGPATQPTAGGGSGSGSASGSASSGERP 289

  Fly   327 -------LPLSGIGNILLAILSGQR--HPPHKDHPLTPLLKDCLAPITCHVAIVAHVRP-EQSYQ 381
                   |.||.:||: :|.|:|.|  |.|::|..||.||:|.|.. .....:||.:.| ..||.
Mouse   290 KEASKINLSLSALGNV-IAALAGNRSTHIPYRDSKLTRLLQDSLGG-NAKTIMVATLGPASHSYD 352

  Fly   382 DALSTIQIASR-------------------------IHRLR------------------RRKHRV 403
            ::|||::.|:|                         |.||:                  |||..|
Mouse   353 ESLSTLRFANRAKNIKNKPRVNEDPKDTLLREFQEEIARLKAQLEKKGMLGKRPRRKSSRRKKAV 417

  Fly   404 PMPLAVGLAQGLGGNGSSAGSGADPSSSEISADTVIYMGPNDDATDGEHPPVYLPSLTAGDNRGV 468
            ..|               ||.   |..|.|.|...   ...||..:..|||  .|.|.|...:.
Mouse   418 SAP---------------AGY---PEGSVIEAWVA---EEEDDNNNNHHPP--QPILEAALEKN- 458

  Fly   469 MSKALKGSGLEKPPSKSASNSPMMM----KKAMAAEKAKKLPGSHTGSLKRQAGAGACSSPMIPH 529
            |...|:.........|:|......:    |:.:..||.|.|.     .|:|:..|....:
Mouse   459 MENYLQDQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLE-----DLRREQQATELLA----- 513

  Fly   530 EQPQIQAMGSPIPIPRHMVSKGSMVPSPKGSPMRRAHPGAALEQLEAGMRKITEEQWIDGPRVSR 594
              .:.:||.|.:.|               |......|.....:.||...::|.|::       .|
Mouse   514 --AKYKAMESKLLI---------------GGRNIMDHTNEQQKMLELKRQEIAEQK-------RR 554

  Fly   595 AKVAEARHLMREVNHVK--------QCETWVDGPKSQSCRSLTACNLPAAGGSQTQGYGFMDAHK 651
            .:..:...|:|:...::        |.|..|   |::..:.|.| .|.|....      ..|.|:
Mouse   555 EREMQQEMLLRDEETMELRGTYSSLQQEVEV---KTKKLKKLYA-KLQAVKAE------IQDQHE 609

  Fly   652 KTM-IRQWVENQTTQVFQSTVSASNSPTALHWKLSQLKQKSLDLPDRPAFNP--EPSLDLNQ--- 710
            :.: :||.:|           .|.|..|      .:||.|.|.:.:   |.|  |.:..:|:
Mouse   610 EYIRVRQDLE-----------EAQNEQT------RELKLKYLIIEN---FIPPEEKNKIMNRLFL 654

  Fly   711 PCFESLPLLDPAPPDGDEDEDSGPSEVPPALPLLDDPLGSRDISQDNLHRMLSRHVSREQLHEAE 775
            .|.|......|..|.|                :.:..:..|..|.....|.:|::        |.
Mouse   655 DCEEEQWRFQPLVPAG----------------VNNSQMKKRPTSAVGYKRPISQY--------AR 695

  Fly   776 LVASRASSSHHPSQRSIDCGLQVTEEEI-ARTMSRDRDHDPSAHPLSALSHCDNISFVSSFNMAC 839
            :..:..|...:.::..:...|.|:...| ....|.|::.||....:..|...|:.....|.....
Mouse   696 VAMAMGSHPRYRAENIMFLELDVSPPAIFEMEFSHDQEQDPRVLHMERLMRLDSFLERPSTTKVR 760

  Fly   840 ESFSECGERARQQFDQLARLHEIFTS 865
            :|.|.|  ::.|:....:..|...||
Mouse   761 KSRSWC--QSPQRMPPPSTAHASMTS 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14535	NP_001285726.1	Motor_domain	44..394	CDD:277568	100/426 (23%)
Kif3c	NP_032471.2	KISc_KIF3	9..367	CDD:276822	100/403 (25%)
		Kinesin	16..367	CDD:278646	98/399 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..292		3/39 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..422		5/39 (13%)
		GBP_C	<463..571	CDD:303769	24/141 (17%)
		coiled coil	540..551	CDD:293879	3/10 (30%)
		coiled coil	560..571	CDD:293879	2/10 (20%)
		Globular. /evidence=ECO:0000255	633..793		33/181 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..796		7/29 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900