Protein Alignment CG14535 and Kif3b

DIOPT Version :10

• Sequence 1: NP_609156.1
• Gene: CG14535 / 34073
• FlyBaseID: FBgn0031955
• Length: 1131
• Species: Drosophila melanogaster
• Sequence 2: NP_032470.3
• Gene: Kif3b / 16569
• MGIID: 107688
• Length: 747
• Species: Mus musculus
• Alignment Length: 909
• Identity: 184/909 - (20%)
• Similarity: 323/909 - (35%)
• Gaps: 291/909 - (32%)

  Fly    49 LRVADRDRNSGGTE-----PDFMALDKKKRQVTLTDPRTACPPPQAAQERAPMVAAPKMFAFDNL 108
            :||..|.|...|.|     ...:.:|.|..||::.:|:      ..:.|      .||.|.||.:
Mouse    10 VRVVVRCRPMNGKEKAASYDKVVDVDVKLGQVSVKNPK------GTSHE------MPKTFTFDAV 62

  Fly   109 FTGEDKQSDVCASALSEVIPAVLEGSDGCLLAMGYPATGQAQTVLGELGGGSGSGSASGSGVACS 173
            :....||.::.......::.:||:|.:|.:.|.|...||:..|:.|..|...            .
Mouse    63 YDWNAKQFELYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGVRGDPE------------K 115

  Fly   174 LGAAPCAIAWLYKGIQERRQKSGARFSVRVSAVGVSATK-PDALSQDLLISHAAESDDSPGIYLR 237
            .|..|.:...::..|...:.:   ::.||.|.:.:...: .|.||:|.......:.....|:|::
Mouse   116 RGVIPNSFDHIFTHISRSQNQ---QYLVRASYLEIYQEEIRDLLSKDQTKRLELKERPDTGVYVK 177

  Fly   238 DDFLGGPTELRAPTAERAALFLDSA---------LAGRLKSSGSTASGSSGCAAPLESALIFTLH 293
            |                .:.|:..:         :..:.:|.|:|........:  .:..:.|:.
Mouse   178 D----------------LSSFVTKSVKEIEHVMNVGNQNRSVGATNMNEHSSRS--HAIFVITIE 224

  Fly   294 VYQYSLSRKGGVAGGRSRLHIIDLGGCAN--RNG------------GLPLSGIGNILLAILSGQ- 343
            ..:..|..:..:..|  :|:::||.|...  :.|            .|.||.:||::.|::.|:
Mouse   225 CSEVGLDGENHIRVG--KLNLVDLAGSERQAKTGAQGERLKEATKINLSLSALGNVISALVDGKS 287

  Fly   344 RHPPHKDHPLTPLLKDCLAPITCHVAIVAHVRPEQSY--QDALSTIQIASR-------------- 392
            .|.|::|..||.||:|.|.. .....:||:|.| .||  ::.|:|::.|:|
Mouse   288 THIPYRDSKLTRLLQDSLGG-NAKTVMVANVGP-ASYNVEETLTTLRYANRAKNIKNKPRVNEDP 350

  Fly   393 -----------IHRLR---------RRKHRVPMPLAVGLAQGLGGNGSSAGSGADPSSSEISADT 437
                       |.||:         |||.|         .:...|.||..|...:....|
Mouse   351 KDALLREFQEEIARLKAQLEKRSIGRRKRR---------EKRREGGGSGGGGEEEEEEGE----- 401

  Fly   438 VIYMGPNDDATDGEHPPVYLPSLTAGDNRGVMSK-ALKGSGLEKPPSKSASNSPMMMKKAMAAEK 501
                   :...||:....|.        |....| .::...:.:..|..|.....::|     ||
Mouse   402 -------EGEEDGDDKDDYW--------REQQEKLEIEKRAIVEDHSLVAEEKMRLLK-----EK 446

  Fly   502 AKKLPGSHTGSLKRQAGA----GACSSPMIPHEQPQIQAMGSPIPIPRHMVSKGSMVPSPKGSPM 562
            .||:.     .|:|:..|    ||           :|:||.|.:     :|...::|....
Mouse   447 EKKME-----DLRREKDAAEMLGA-----------KIKAMESKL-----LVGGKNIVDHTN---- 486

  Fly   563 RRAHPGAALEQLEAGMRKITEEQWIDGPRVSRAKVAEARHLMREVNHVKQC---------ETW-- 616
                     ||     :||.|::        |.::||.:...||:....:.         ||:
Mouse   487 ---------EQ-----QKILEQK--------RQEIAEQKRREREIQQQMESRDEETLELKETYTS 529

  Fly   617 ----VDGPKSQSCRSLTACNLPAAGGSQTQGYGFMDAHKKTMIRQWVE---NQTTQVFQSTVSAS 674
                || .|::..:.|.: .|.|.   :.:.:...:.|.|.  ||.:|   |:.|:
Mouse   530 LQQEVD-IKTKKLKKLFS-KLQAV---KAEIHDLQEEHIKE--RQELEQTQNELTR--------- 578

  Fly   675 NSPTALHWKLSQLKQKSLDLPDRPAFNP--EPSLDLNQPCFESLPLLDPAPPDGDEDEDSGPSEV 737
                       :||.|.|.:.:   |.|  |.:..:|:..|             |::||..  ::
Mouse   579 -----------ELKLKHLIIEN---FIPLEEKNKIMNRSFF-------------DDEEDHW--KL 614

  Fly   738 PPALPLLDDPLGSRDISQDNLHRMLSRH------VSREQLHEAELV-------ASRASSSHH-PS 788
            .|...|.:..:..|.:|.....|.||:|      :..|..:.||.:       .||.:..:. |:
Mouse   615 HPITRLENQQMMKRPVSAVGYKRPLSQHARMSMMIRPEPRYRAENIMLLELDMPSRTTRDYEGPA 679

  Fly   789 -----QRSIDCGLQVTEEEI---ARTMSRDRDHDPSAHPLSALSHCDNISFVSSFNMACESFSE 844
                 |.::|..|| .|:||   |.:........|.|.|.|......:.|  ||.|.|.:.:.:
Mouse   680 ISPKVQAALDAALQ-DEDEIQVDASSFESTASRKPKARPKSGRKSGSSSS--SSGNPASQFYPQ 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14535	NP_609156.1	Motor_domain	44..394	CDD:473979	81/401 (20%)
Kif3b	NP_032470.3	KISc_KIF3	8..340	CDD:276822	81/378 (21%)
		Smc	<355..>581	CDD:440809	60/333 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	374..412		11/58 (19%)
		Globular	580..747		43/182 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	698..747		11/45 (24%)