DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14535 and Kif12

DIOPT Version :9

Sequence 1:	NP_001285726.1	Gene:	CG14535 / 34073	FlyBaseID:	FBgn0031955	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_001304281.1	Gene:	Kif12 / 16552	MGIID:	1098232	Length:	643	Species:	Mus musculus

Alignment Length:	700	Identity:	150/700 - (21%)
Similarity:	218/700 - (31%)	Gaps:	198/700 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 RAPMVAAPKMFAFDNLFTGEDKQSDVC-ASALSEVIPAVLEGSDGCLLAMGYPATGQAQTVLGEL 156
            |...|:....|.|..:..|...|.||. |..:..:....|.|....:...|...:|:..|:.|..
Mouse    54 RTLQVSPDVAFRFGAVLDGARTQEDVFRACGVKRLGELALRGFSCTVFTFGQTGSGKTYTLTGPP 118

  Fly   157 GGGSGSGSASGSGVACSL-GAAPCAIAWLYKGIQERRQKSGARFSVRVSAVGVSATKPDALSQDL 220
            ..|      .|..|..|| |.......||.    :|.|...:..::|.|.:.:.    :....||
Mouse   119 PQG------EGVPVPPSLAGIMQRTFTWLL----DRVQHLDSPVTLRASYLEIY----NEQVWDL 169

  Fly   221 LISHAAESDDSP-----------GIYLRDDFLGGPTELRA---PTAERAALFLDSALAGRLKSSG 271
            |      |..||           |.|:.        :||.   .:.|.....|...|:.|..||.
Mouse   170 L------SLGSPRPLPVRWTKARGFYVE--------QLRVVEFGSLEALMELLQMGLSRRRSSSH 220

  Fly   272 STASGSSGCAAPLESALIFTLHVYQYSLSRKGGV------AGGRSRLHIIDLGG-----CANRNG 325
            :....||      .|..:.|||:.:.:..:...|      .||  :|..:||.|     .....|
Mouse   221 TLNQASS------RSHALLTLHISRPTSQQVPPVDLGEPPVGG--KLCFVDLAGSEKVAATGSQG 277

  Fly   326 GLPLS---------GIGNILLAILSGQR---HPPHKDHPLTPLLKDCLA--PITCHVAIVAHVRP 376
            .|.|.         .:|:.:..:|..||   |.|.:|..||.||.|.|.  .:|..||.|:   |
Mouse   278 QLMLEANSINRSLLALGHCISLLLDPQRKQNHIPFRDSKLTKLLADSLGGRGVTLMVACVS---P 339

  Fly   377 E-QSYQDALSTIQIASRIHRLRRRKHRVPMPLAVGLAQGLGGNGSSAGSGADPSSSEISADTVIY 440
            . |...:.|||::.|||..|:..|......|                  |..| ..::..:.:..
Mouse   340 SAQCLPETLSTLRYASRAQRITTRPQGPKSP------------------GVKP-PQQVENELLRL 385

  Fly   441 MGPNDDATDGEHPPVYLPSL--TAGDNRGV-MSKA------------LKGSGLEKPPSKSASNSP 490
            ...|      .|....|..:  ||....|. |:.|            |:...|.|...:..|:..
Mouse   386 QEEN------RHLRFQLDQMHTTAPGAHGARMAWAQRNLYGMLQEFMLENERLRKEMRQLRSSRD 444

  Fly   491 M-MMKKAMAAEKAKKLPGSHTGS--LKRQAGAGACSSPMIP----HEQPQIQAMGSPIPIPRHMV 548
            : ..::.:.|::...|......:  |.:|.....|...|:|    |..|.:.......|:.|
Mouse   445 LARAEQRVLAQQVHDLERRLLSACPLPQQGSTPVCPCRMVPAASCHALPPLCYCHHFCPLCR--- 506

  Fly   549 SKGSMVPSPKGS-PMRRAH-PGAALEQLEAG--MRKITEEQWIDGPRVSRAKVAEARH------- 602
                 ||....: |.|..| |...||....|  .:.:....|...|....||....|.
Mouse   507 -----VPLAHWTCPRRECHMPQQVLEPEAPGHISQSVWPPPWAPPPSPGSAKPPRERSQSDWTQT 566

  Fly   603 ------LMREVNHVKQCETWVDGPKSQSCRSLTACNLPAAGGSQTQGYGFMDAHKKTMIRQWVEN 661
                  ||.|       |.....|             |.:.|.....||.........:...:|.
Mouse   567 RVLAEMLMGE-------EVVPSAP-------------PLSAGPSNMPYGLRGGSGIPNLTPRLET 611

  Fly   662 QTTQVFQSTVSASNSPTALHWKLSQLKQKSLDLPDRPAFNPEPSLDLNQP 711
            .|.|:        ||  :||  |||.:             |:||.|...|
Mouse   612 LTQQI--------NS--SLH--LSQRQ-------------PQPSEDTQSP 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14535	NP_001285726.1	Motor_domain	44..394	CDD:277568	84/342 (25%)
Kif12	NP_001304281.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		KISc	25..358	CDD:276812	84/342 (25%)
		Kinesin	31..360	CDD:278646	84/344 (24%)
		Kinesin-relat_1	<379..464	CDD:289481	14/90 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..562		6/29 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	580..643		19/94 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900