DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rack1 and Wdr31

DIOPT Version :9

Sequence 1:	NP_001260218.1	Gene:	Rack1 / 34070	FlyBaseID:	FBgn0020618	Length:	318	Species:	Drosophila melanogaster
Sequence 2:	NP_001011976.2	Gene:	Wdr31 / 298096	RGDID:	1309367	Length:	367	Species:	Rattus norvegicus

Alignment Length:	299	Identity:	77/299 - (25%)
Similarity:	123/299 - (41%)	Gaps:	54/299 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSETLQLRGT---LIGHNGWVTQIATNPKDPDTIISASRDKTLIV--WKLTRDEDTNYGYPQKRL 60
            :.|.:|.:.:   :..|...|:.:|.  .:.|..||..:|||.:|  ||.        |:..:|.
  Rat    45 IEERVQTKASQEYIPAHVDTVSVVAA--LNSDLCISGGKDKTAVVYNWKT--------GHVVRRF 99

  Fly    61 YGHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTR-RFEGHTKDVLSVAFSADNRQIVSG 124
            .||...|:.:......|...|.|.|:|:.:|||......| :..||...|..:|.|.|:.|:.:|
  Rat   100 IGHEREITKIACIPKSNQFFSASRDKTVLMWDLQGSSQPRQQLSGHAMVVTGLAVSPDSSQLCTG 164

  Fly   125 SRDKTIKLWNT-LAEC--KFTIQED--GHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCK 184
            |||.::.||:. ..:|  :.::..:  .|..||.        ..|.||....|:|:::|:....:
  Rat   165 SRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVP--------REPYIVQTSEDKTIRLWDCRGLQ 221

  Fly   185 LKNNHHGHNGYLNTVTVSPDGSLCTS-----GGKDSKALLWDLNDGKNLYTLE-------HNDII 237
            :.:.............||.||..|.|     ||:..:|.||||..     |.|       |...:
  Rat   222 MAHVFPTKQHIQTHCEVSVDGHTCVSCSSGFGGEGCEATLWDLRQ-----TRERMCEYKGHFQTV 281

  Fly   238 NALCFSPNRYWL-----CVAYGPSIKIWDL---ACKKTV 268
            .:..|.|....|     ..|:...:|||:.   ||..|:
  Rat   282 ASCVFLPKSAALMPMIATSAHDSKVKIWNQDTGACLSTL 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rack1	NP_001260218.1	WD40	7..312	CDD:238121	75/293 (26%)
		WD40 repeat	18..62	CDD:293791	13/45 (29%)
		WD40 repeat	68..104	CDD:293791	9/36 (25%)
		WD40 repeat	109..145	CDD:293791	12/38 (32%)
		WD40 repeat	153..190	CDD:293791	6/36 (17%)
		WD40 repeat	196..232	CDD:293791	14/40 (35%)
		WD40 repeat	237..280	CDD:293791	10/40 (25%)
		WD40 repeat	287..311	CDD:293791
Wdr31	NP_001011976.2	WD40	58..344	CDD:238121	75/286 (26%)
		WD40 repeat	65..101	CDD:293791	13/45 (29%)
		WD40 repeat	107..144	CDD:293791	9/36 (25%)
		WD40 repeat	149..184	CDD:293791	12/34 (35%)
		WD40 repeat	192..227	CDD:293791	9/42 (21%)
		WD40 repeat	234..275	CDD:293791	15/45 (33%)
		WD40 repeat	285..321	CDD:293791	10/36 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0279
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900