DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rack1 and Wsb2

DIOPT Version :9

Sequence 1:	NP_001260218.1	Gene:	Rack1 / 34070	FlyBaseID:	FBgn0020618	Length:	318	Species:	Drosophila melanogaster
Sequence 2:	XP_008767442.1	Gene:	Wsb2 / 288692	RGDID:	1359599	Length:	406	Species:	Rattus norvegicus

Alignment Length:	299	Identity:	73/299 - (24%)
Similarity:	130/299 - (43%)	Gaps:	45/299 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 RDKTL----IVWKLTRDEDTNYGYPQKRLYGHSH----FISDVVLSSDGNYALSGSWDQTLRLWD 92
            ::|||    |||.|......:  .|.::|:...|    .:|.::|::..|       |..:::|:
  Rat    86 KEKTLDCGQIVWGLAFSPWPS--PPSRKLWLRHHPQVPDVSCLILATGLN-------DGQIKIWE 141

  Fly    93 LAAGKTTRRFEGHTKDVLSVAFSADNRQI-VSGSRDKTIKLWNTLAECKFTIQEDGHTDWVSCVR 156
            :..|.......||...|..::|:.:...| ||.|||||:::|:.....|......||..||.|..
  Rat   142 VQTGLLLLNLSGHQDVVRDLSFTPNGSLILVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCS 206

  Fly   157 FSPNHSNPIIVSCGWDRTVKVWNLANCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWD 221
            .||:.|  ::.|...:::|.:|::.:..|.....||...:.:...|||.:|..:...|:..::||
  Rat   207 ISPDCS--MLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWD 269

  Fly   222 LNDGKNLYTLEHNDI-------------INALCFSPNRYWLC-VAYGPSIKIWDLACKKTVEELR 272
            ...|:.|.:|.|..:             :.::||||...:|. ||....::||.|
  Rat   270 PYTGERLRSLHHTQLEAPVDDSDVHMSSLRSVCFSPEGLYLATVADDRLLRIWAL---------- 324

  Fly   273 PEVVSPTSKADQPQCLSLAWSTDGQTLFAGYSDNTIRVW 311
             |:.:|.:.|.....|...:...|..:..|..|..::.|
  Rat   325 -ELKAPVAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFW 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rack1	NP_001260218.1	WD40	7..312	CDD:238121	73/299 (24%)
		WD40 repeat	18..62	CDD:293791	9/29 (31%)
		WD40 repeat	68..104	CDD:293791	6/35 (17%)
		WD40 repeat	109..145	CDD:293791	12/36 (33%)
		WD40 repeat	153..190	CDD:293791	8/36 (22%)
		WD40 repeat	196..232	CDD:293791	9/35 (26%)
		WD40 repeat	237..280	CDD:293791	12/43 (28%)
		WD40 repeat	287..311	CDD:293791	4/23 (17%)
Wsb2	XP_008767442.1	WD40 repeat	31..91	CDD:293791	2/4 (50%)
		WD40	32..369	CDD:225201	73/299 (24%)
		WD40	123..362	CDD:238121	62/258 (24%)
		WD40 repeat	159..197	CDD:293791	11/37 (30%)
		WD40 repeat	202..238	CDD:293791	9/37 (24%)
		WD40 repeat	246..291	CDD:293791	11/44 (25%)
		WD40 repeat	298..330	CDD:293791	11/42 (26%)
		WD40 repeat	338..374	CDD:293791	5/25 (20%)
		SOCS_WSB_SWIP	366..404	CDD:239702
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D805365at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010