DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rack1 and rack-1

DIOPT Version :9

Sequence 1:	NP_001260218.1	Gene:	Rack1 / 34070	FlyBaseID:	FBgn0020618	Length:	318	Species:	Drosophila melanogaster
Sequence 2:	NP_501859.1	Gene:	rack-1 / 177895	WormBaseID:	WBGene00010556	Length:	325	Species:	Caenorhabditis elegans

Alignment Length:	323	Identity:	218/323 - (67%)
Similarity:	262/323 - (81%)	Gaps:	7/323 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSETLQLRGTLIGHNGWVTQIATNPK-DPDTIISASRDKTLIVWKLTR----DEDTNYGYPQKRL 60
            :.|.::|.|||.||.||||||||..: |..|::|:|||||::||.:..    ||.. .|.|.:.|
Worm     2 VQEQMKLTGTLEGHTGWVTQIATYTRNDKTTVLSSSRDKTILVWDVDSVAPVDEGP-IGRPVRSL 65

  Fly    61 YGHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQIVSGS 125
            .||:||:||||:||||.:|||||||:|||||||..|.:||:|..|||||||||||||||||||||
Worm    66 TGHNHFVSDVVISSDGQFALSGSWDKTLRLWDLNQGVSTRQFISHTKDVLSVAFSADNRQIVSGS 130

  Fly   126 RDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCKLKNNHH 190
            |||:||||||||:||:||.:|.||||||.|||||::.:|:|||.|||:.||||||.||:||.||.
Worm   131 RDKSIKLWNTLAQCKYTITDDCHTDWVSTVRFSPSNRDPVIVSAGWDKVVKVWNLGNCRLKTNHI 195

  Fly   191 GHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLEHNDIINALCFSPNRYWLCVAYGP 255
            ||.||:||||||||||||.|||||.:|:|||||:||:||||..||:|||:.|||||||||.|.|.
Worm   196 GHTGYVNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLPGNDVINAMSFSPNRYWLCAAVGS 260

  Fly   256 SIKIWDLACKKTVEELRPEVVSP-TSKADQPQCLSLAWSTDGQTLFAGYSDNTIRVWQVSVSA 317
            |||||||..||.:|||:||:.|. :|:...|||:|||||.|||||||||:||.|||:|||:.|
Worm   261 SIKIWDLEDKKEIEELKPEIASSGSSRGSSPQCISLAWSQDGQTLFAGYTDNIIRVYQVSIRA 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rack1	NP_001260218.1	WD40	7..312	CDD:238121	213/310 (69%)
		WD40 repeat	18..62	CDD:293791	21/48 (44%)
		WD40 repeat	68..104	CDD:293791	26/35 (74%)
		WD40 repeat	109..145	CDD:293791	32/35 (91%)
		WD40 repeat	153..190	CDD:293791	24/36 (67%)
		WD40 repeat	196..232	CDD:293791	28/35 (80%)
		WD40 repeat	237..280	CDD:293791	29/43 (67%)
		WD40 repeat	287..311	CDD:293791	19/23 (83%)
rack-1	NP_501859.1	WD40	<2..317	CDD:225201	213/315 (68%)
		WD40	8..318	CDD:238121	213/310 (69%)
		WD40 repeat	73..109	CDD:293791	26/35 (74%)
		WD40 repeat	114..150	CDD:293791	32/35 (91%)
		WD40 repeat	158..195	CDD:293791	24/36 (67%)
		WD40 repeat	201..237	CDD:293791	28/35 (80%)
		WD40 repeat	242..286	CDD:293791	29/43 (67%)
		WD40 repeat	293..317	CDD:293791	19/23 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165769
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0279
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4446
Inparanoid	1	1.050	456	1.000	Inparanoid score	I886
Isobase	1	0.950	-	0.993157	Normalized mean entropy	S231
OMA	1	1.010	-	-		QHG53895
OrthoDB	1	1.010	-	-		D372857at33208
OrthoFinder	1	1.000	-	-		FOG0003692
OrthoInspector	1	1.000	-	-		oto19922
orthoMCL	1	0.900	-	-		OOG6_101640
Panther	1	1.100	-	-	LDO	PTHR19868
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R476
SonicParanoid	1	1.000	-	-		X2556
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.790