DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rack1 and T05A8.5

DIOPT Version :9

Sequence 1:	NP_001260218.1	Gene:	Rack1 / 34070	FlyBaseID:	FBgn0020618	Length:	318	Species:	Drosophila melanogaster
Sequence 2:	NP_494344.1	Gene:	T05A8.5 / 173617	WormBaseID:	WBGene00020231	Length:	378	Species:	Caenorhabditis elegans

Alignment Length:	238	Identity:	56/238 - (23%)
Similarity:	94/238 - (39%)	Gaps:	45/238 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 HNGWVTQIATNP------KDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDVVL 72
            ||.|......|.      ....::|:|.|:.||..|....:..   ..|.....||...::.||
Worm    90 HNMWSNSCEINKICYRNFIAKHSLIAAGRNGTLTHWMFNHEPG---DLPNVVFDGHKFGVTGVV- 150

  Fly    73 SSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQIVSGSRDKTIKLW---- 133
            |.:.|..:|||.|.::::|||.:.|..|....:...|..:|::.:  .:...|.||:::||
Worm   151 SINENQFMSGSRDCSVKIWDLESAKCVRTQTINRNLVTHMAYNGN--LVAQTSEDKSVRLWDPRN 213

  Fly   134 -NTLAE----------CKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCKLKN 187
             :.:.|          |:|    ||...:.||   |...:|.   .|    .:..:::.|.:...
Worm   214 ASVVTEFPRKRHIQMFCEF----DGANRFFSC---SNGFNND---GC----EITSYDVRNPRQSR 264

  Fly   188 NHHGHNG---YLNTVTVSPDGSLCTSGGKDSKALLWDL-NDGK 226
            ...||.|   .|:.|.:.....|..|...|.:..||.: .||:
Worm   265 EARGHEGNVTSLSIVQMDQTKRLLASVSADRQIRLWKIEEDGQ 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rack1	NP_001260218.1	WD40	7..312	CDD:238121	56/238 (24%)
		WD40 repeat	18..62	CDD:293791	8/49 (16%)
		WD40 repeat	68..104	CDD:293791	13/35 (37%)
		WD40 repeat	109..145	CDD:293791	10/50 (20%)
		WD40 repeat	153..190	CDD:293791	6/36 (17%)
		WD40 repeat	196..232	CDD:293791	9/32 (28%)
		WD40 repeat	237..280	CDD:293791
		WD40 repeat	287..311	CDD:293791
T05A8.5	NP_494344.1	WD40	54..301	CDD:392136	53/230 (23%)
		WD40 repeat	147..182	CDD:293791	13/35 (37%)
		WD40 repeat	187..221	CDD:293791	8/35 (23%)
		WD40 repeat	227..267	CDD:293791	10/53 (19%)
		WD40	263..>345	CDD:392136	12/45 (27%)
		WD40 repeat	276..317	CDD:293791	9/32 (28%)
		WD40 repeat	324..364	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0279
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900