DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7115 and PPM1D

DIOPT Version :9

Sequence 1:	NP_001260216.1	Gene:	CG7115 / 34069	FlyBaseID:	FBgn0027515	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_003611.1	Gene:	PPM1D / 8493	HGNCID:	9277	Length:	605	Species:	Homo sapiens

Alignment Length:	406	Identity:	93/406 - (22%)
Similarity:	143/406 - (35%)	Gaps:	168/406 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 TGISFFAVFDGHGGEFAADFAKDVLVKNIYNKIIEMSKLLKTEGNSGDYDKSPYLARKQSRKDAN 201
            :.::||||.|||||..||.||::.|...|                               :|...
Human    96 SSVAFFAVCDGHGGREAAQFAREHLWGFI-------------------------------KKQKG 129

  Fly   202 KENTEPTAGVMRKDSLRKAHSTTADCSAIKQKTTEASIADIYTVQLNSAMRASGNLGAAKDSFLN 266
            ..::|| |.|               |:||::                              .||
Human   130 FTSSEP-AKV---------------CAAIRK------------------------------GFL- 147

  Fly   267 NNNNGQNGAANAPPPNYEAKCYIEHGRINFGKLITDEIMSADYKLVEQAKRATNI---AGTTALI 328
                               .|::...:                ||.|..|..|.:   :||||.:
Human   148 -------------------ACHLAMWK----------------KLAEWPKTMTGLPSTSGTTASV 177

  Fly   329 AIVQGSKLIVANVGDSRGVMYDWRGI----------AIPLSFDHKPQQVRERKRIHDAGGFI--- 380
            .|::|.|:.||:||||..|:    ||          |:.::.||||:..:||:||...||.:
Human   178 VIIRGMKMYVAHVGDSGVVL----GIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNK 238

  Fly   381 --AFRGVWRVAGV-----------------LATSRALGD---YPLKDKNLVIA-TPDILTFELND 422
              ..|.||:...:                 ||.:|||||   |.......|:: .||.....|:.
Human   239 SGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDP 303

  Fly   423 HKPHFLILASDGLWDTFSNEEACTFALEHLKEP----DFG---AKSLAMESYKRG-----SVDNI 475
            .|..::||.|||||:....::|.:...:..::.    :.|   ||.|...:..|.     ..||.
Human   304 QKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNT 368

  Fly   476 TVLVIVFKNDVYKIGS 491
            :.:||....:|...|:
Human   369 SAIVICISPEVDNQGN 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7115	NP_001260216.1	PP2Cc	111..482	CDD:238083	91/395 (23%)
PPM1D	NP_003611.1	Interaction with CHEK1. /evidence=ECO:0000269\|PubMed:15870257	1..101		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..90
		PP2C	67..368	CDD:278884	88/388 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..591
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900