DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7115 and PPM1G

DIOPT Version :9

Sequence 1:	NP_001260216.1	Gene:	CG7115 / 34069	FlyBaseID:	FBgn0027515	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_817092.1	Gene:	PPM1G / 5496	HGNCID:	9278	Length:	546	Species:	Homo sapiens

Alignment Length:	542	Identity:	135/542 - (24%)
Similarity:	209/542 - (38%)	Gaps:	163/542 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 AVLGRRPRMEDRFIIEENINNNTGISFFAVFDGHGGE----FAADFAKDVLVKNIYNKIIEMSKL 175
            |:.|.|..|||.......:::.|  :.|:|:||||||    :.|.:..|         ||:..|.
Human    31 AMQGWRVSMEDAHNCIPELDSET--AMFSVYDGHGGEEVALYCAKYLPD---------IIKDQKA 84

  Fly   176 LKTEGNSGDYDKSPYLA--RKQSRKDANKENTE----PTAGVMRKDSLRKAHSTTADCSAIKQKT 234
            .| ||......:..:||  .|.:.::..||..:    ||.....|:.:........:.:|:..:.
Human    85 YK-EGKLQKALEDAFLAIDAKLTTEEVIKELAQIAGRPTEDEDEKEKVADEDDVDNEEAALLHEE 148

  Fly   235 TEASIADIYTVQLNSA------MRASGNLGAAKDSFLNNNNNGQNGAA-----NAPPPNYE---- 284
            ...:|.::.|....:.      .::.|..|....|      .|.||.|     ....|:.|
Human   149 ATMTIEELLTRYGQNCHKGPPHSKSGGGTGEEPGS------QGLNGEAGPEDSTRETPSQENGPT 207

  Fly   285 AKCY----------IEHGRINFGKLITDE----IMSADYKLVEQAK------------------- 316
            ||.|          .|.|::....:.|.|    ..||..||...||
Human   208 AKAYTGFSSNSERGTEAGQVGEPGIPTGEAGPSCSSASDKLPRVAKSKFFEDSEDESDEAEEEEE 272

  Fly   317 ---------------RATN----------------------------------IAGTTALIAIVQ 332
                           .|.|                                  .:||||::|:::
Human   273 DSEECSEEEDGYSSEEAENEEDEDDTEEAEEDDEEEEEEMMVPGMEGKEEPGSDSGTTAVVALIR 337

  Fly   333 GSKLIVANVGDSRGVMYDWRGIAIPLSFDHKPQQVRERKRIHDAGGFIAFRGVWRVAGVLATSRA 397
            |.:|||||.||||.|:.: .|.|:.:|:||||:...|..||.:|||.:...|  ||.|.|..|||
Human   338 GKQLIVANAGDSRCVVSE-AGKALDMSYDHKPEDEVELARIKNAGGKVTMDG--RVNGGLNLSRA 399

  Fly   398 LGDYPLK-DKNL------VIATPDILTFEL-NDHKPHFLILASDGLWDTFSNEEACTFALEHLKE 454
            :||:..| :|||      :.|.|||....| :||:  |:::|.||:|:..|::|...|....:.:
Human   400 IGDHFYKRNKNLPPEEQMISALPDIKVLTLTDDHE--FMVIACDGIWNVMSSQEVVDFIQSKISQ 462

  Fly   455 PDFGA--------------KSLAMESYKRGS-VDNITVLVIVFK-NDVYKIGSSAGKAG-EESLK 502
            .|...              :.||.::...|: .||:|.::|.|| .:..::...:||.. ||.|.
Human   463 RDENGELRLLSSIVEELLDQCLAPDTSGDGTGCDNMTCIIICFKPRNTAELQPESGKRKLEEVLS 527

  Fly   503 VPAKSQPVAPAVVQRSNSIKTK 524
            .....        :..||.|.|
Human   528 TEGAE--------ENGNSDKKK 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7115	NP_001260216.1	PP2Cc	111..482	CDD:238083	124/496 (25%)
PPM1G	NP_817092.1	PP2Cc	25..>110	CDD:214625	26/90 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..139		3/22 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..328		24/172 (14%)
		PP2Cc	<324..505	CDD:238083	66/185 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	512..546		9/38 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810