DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7115 and phlpp1

DIOPT Version :9

Sequence 1:	NP_001260216.1	Gene:	CG7115 / 34069	FlyBaseID:	FBgn0027515	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	XP_004915365.2	Gene:	phlpp1 / 100497530	XenbaseID:	XB-GENE-6458029	Length:	1533	Species:	Xenopus tropicalis

Alignment Length:	644	Identity:	121/644 - (18%)
Similarity:	202/644 - (31%)	Gaps:	236/644 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 PEVIFCGLILFVLLL---------------YLQAVDVWSRSILGRIQATLGRQKAVKMMELSASA 98
            |:.:||...|..|||               .|:.:||....:|......|.:..:::.:..||:.
Frog   737 PDRLFCTSALRKLLLGYNQLQRLPELIENNQLEVLDVQHNQLLELPANLLLKLNSLRCLNASANH 801

  Fly    99 GDHQSWEEMKQQSSAFAVLGRRPRMEDRFIIEENINNNTGISFFAVFDGHGGEFAADFAKDVLVK 163
            .:......:.::|.:.        :::.::...|:                    .|....:|:.
Frog   802 LETLPATCLSEESHSM--------LQELYLTNNNL--------------------TDKCVPLLMG 838

  Fly   164 NIYNKIIEM----------SKLLKTEGNSGDYDKSPYLARKQSRKDANKENTEPTAGVMRKDSLR 218
            :.:.||:.|          ||:.|.| ...:.|.|           .||....||. :|   :.|
Frog   839 HPHLKILHMAFNHLQTFPASKMAKLE-ELEEIDIS-----------GNKLKAMPTT-IM---NCR 887

  Fly   219 KAHSTTADCSAIKQKTTEASIADIYTVQLN-----------------SAMRASGNLGAAKD---- 262
            :.|:..|..:.::.......:::|..|.|:                 ..:..:||.....|
Frog   888 RMHTVIAHSNCLEVFPEVMQLSEIKCVDLSCNELTEITLPENLPPRLQELDLTGNARLLLDHKTL 952

  Fly   263 SFLNNN---------NNGQNGAANAPPP-----------------------------NYEAKCYI 289
            ..||:|         :.|.:|:..:..|                             |.||...:
Frog   953 ELLNSNIRFLKVDQPSCGFSGSEASGVPAVWSHGYAEASGVKSKLCVASLLVNNFCDNREAVYGV 1017

  Fly   290 EHGRIN----------FGKLITDEIMSA----DYK----LVEQAKRAT---NIAGTTALIAIVQG 333
            ..|..|          ...::.||:...    :|.    ||.|.|..|   .:.|:..|..|...
Frog  1018 FDGERNVEVPSLLQCTMSDILADELQKTKSEEEYMGNTFLVMQRKLGTAGQKLGGSAVLCHIKHD 1082

  Fly   334 S-------KLIVANVGDSRGVMYDWRGIAIPLSFDHKPQQV---------RERKRIHDAGGFIAF 382
            .       .|..||||..:.|          :..|.||..:         .|.|||......|..
Frog  1083 PMDPAGCFTLTTANVGKCQTV----------ICRDGKPLNLSKHLTVSCEEELKRIKQHKAIITE 1137

  Fly   383 RGVWRVAGVLATSRALGDYPLKDKNLVIATPDILTFELNDHKPHFLILASDGLWDTFSNEEACTF 447
            .|  :|.||..::|.|| |.....: |...|.:.:..|.. :..|.||.|.||||:.|.||
Frog  1138 DG--KVNGVTDSTRILG-YTFLHPS-VTPRPHVQSVTLTP-QDEFFILGSKGLWDSLSMEE---- 1193

  Fly   448 ALEHLKE-PD--FGAKSLAMESYKRGSVDNITVLVI------------------------VFKND 485
            |:|.::. ||  ..:|.|...:...|...::..:|:                        :|...
Frog  1194 AVETVRNVPDALAASKKLCSLAQSYGCSGSLCAVVVQLNVTEDCICCCELNGGMPPPSPGIFTPS 1258

  Fly   486 VYKI------------GSSAGKAGEESLKV-----------PAKSQPVAPAVVQRSNSI 521
            |..:            .||:|.|.|.|.::           .|..:|  |||....|.:
Frog  1259 VNVVIKDRAPDSLGMPSSSSGLASEISSEISTSEMSSEVGSTASDEP--PAVSLHENGV 1315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7115	NP_001260216.1	PP2Cc	111..482	CDD:238083	93/503 (18%)
phlpp1	XP_004915365.2	RA_PHLPP1	136..332	CDD:340760
		PH_PHLPP-like	339..435	CDD:270131
		PLN00113	406..>930	CDD:215061	38/236 (16%)
		leucine-rich repeat	443..465	CDD:275380
		leucine-rich repeat	466..496	CDD:275380
		leucine-rich repeat	497..519	CDD:275380
		leucine-rich repeat	520..542	CDD:275380
		leucine-rich repeat	543..565	CDD:275380
		leucine-rich repeat	566..603	CDD:275380
		leucine-rich repeat	614..636	CDD:275380
		leucine-rich repeat	638..657	CDD:275380
		leucine-rich repeat	658..699	CDD:275380
		leucine-rich repeat	700..722	CDD:275380
		leucine-rich repeat	723..745	CDD:275380	3/7 (43%)
		leucine-rich repeat	746..767	CDD:275380	4/20 (20%)
		leucine-rich repeat	768..791	CDD:275380	5/22 (23%)
		leucine-rich repeat	792..815	CDD:275380	2/22 (9%)
		leucine-rich repeat	818..841	CDD:275380	3/42 (7%)
		leucine-rich repeat	842..865	CDD:275380	7/23 (30%)
		leucine-rich repeat	911..933	CDD:275380	3/21 (14%)
		PP2Cc	980..1229	CDD:214625	60/267 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910